Abstract | BACKGROUND/AIMS: METHODS: Male Wistar rats were fed a standard rodent chow or an HFD with intragastric administration of NAC or ALA for ten weeks. The collected samples were subjected to pathohistological evaluation. Real-time PCR and western blot approaches were used to check whether NAC or ALA impacts MMP2/9 expression. RESULTS:
Antioxidant supplementation markedly reduced the number of circulating inflammatory cytokines, and tissue macrophage infiltration. Moreover, NAC and ALA have a divergent impact on MMP2 and MMP9 expression in different adipose tissue localization. CONCLUSION: Based on our results, we speculate that NAC and ALA have a prominent effect on the MMP2/9 functions under obesity conditions.
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Authors | Marta Wołosowicz, Bartłomiej Łukaszuk, Irena Kasacka, Adrian Chabowski |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 56
Issue 2
Pg. 166-179
(Apr 15 2022)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 35420738
(Publication Type: Journal Article)
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Copyright | © Copyright by the Author(s). Published by Cell Physiol Biochem Press. |
Chemical References |
- Antioxidants
- Thioctic Acid
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Acetylcysteine
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Topics |
- Acetylcysteine
(therapeutic use)
- Animals
- Antioxidants
(metabolism)
- Diet, High-Fat
(adverse effects)
- Dietary Supplements
- Male
- Matrix Metalloproteinase 2
(genetics, metabolism)
- Matrix Metalloproteinase 9
(genetics, metabolism)
- Obesity
(drug therapy, etiology, metabolism)
- Rats
- Rats, Wistar
- Subcutaneous Fat
(metabolism)
- Thioctic Acid
(pharmacology, therapeutic use)
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