Abstract | AIMS: METHODS: 465 patients with T2DM ( stroke or AMI, n = 234; non stroke or AMI, n = 231) were recruited. Clinical characteristics, and NE and PR3 concentration were measured in all subjects. Semi-quantitative analysis of immunohistochemistry staining for NE and PR3 was performed in detached emboli and stable plaques. RESULTS: Patients with stroke or AMI had a higher level of NE and PR3, with a more pronounced increase in more severe cases (higher mRS score in stroke and Gensini score in AMI) and associated with clinical markers. An increase in NE and PR3 was an independent risk factor for stroke (OR = 4.318, P = 0.017; OR = 2.979, P = 0.048, respectively) and AMI (OR = 8.385, P = 0.015; OR = 5.540, P = 0.047). Finally, immunohistochemistry staining revealed that the NE and PR3 positive area increased significantly in detached emboli compared with stable plaques. CONCLUSION: Increased NE and PR3 was associated with occurrence and severity of stroke and AMI in patients with T2DM. Enriched NE and PR3 in detached emboli may be associated with plaque vulnerability.
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Authors | Lihong Wang, Jie Pan, Yifan Sun, Shuhang Zong, Rui Zhang, Yue Li, Zhiyan Yu, Jun Liu, Shufei Zang |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 186
Pg. 109853
(Apr 2022)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 35341779
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
- Leukocyte Elastase
- Myeloblastin
|
Topics |
- Diabetes Mellitus, Type 2
(complications)
- Humans
- Leukocyte Elastase
- Myeloblastin
- Myocardial Infarction
(etiology)
- Stroke
(etiology)
|