HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Myeloblastin (Proteinase 3)

Subscribe to New Research on Myeloblastin

A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.

Also Known As:

Proteinase 3; Azurophil Granule Protein 7; Leukocyte Proteinase 3; Myeloblastin, Human; N-Proteinase 4; Neutrophil Proteinase 3, Human; Neutrophil Proteinase 4; Human Myeloblastin; Proteinase 3, Leukocyte; Proteinase 3, Neutrophil; Neutrophil Proteinase 3; Wegener Autoantigen

Networked: 496 relevant articles (16 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Serine Proteases: 3067
        Serine Endopeptidases
        Myeloblastin: 496
      - Endopeptidases: 212
        Serine Endopeptidases
        Myeloblastin: 496

Experts

1.	Kallenberg, Cees G M: 20 articles (10/2014 - 01/2002)
2.	Stegeman, Coen A: 17 articles (12/2013 - 01/2002)
3.	Csernok, Elena: 14 articles (04/2015 - 06/2002)
4.	Gross, Wolfgang L: 12 articles (04/2015 - 02/2004)
5.	Segelmark, M: 9 articles (02/2014 - 05/2000)
6.	Limburg, Pieter C: 9 articles (09/2009 - 02/2002)
7.	Limburg, P C: 9 articles (05/2009 - 09/2000)
8.	Guillevin, Loïc: 8 articles (11/2015 - 05/2007)
9.	Mouthon, Luc: 8 articles (11/2015 - 05/2007)
10.	Jenne, Dieter E: 8 articles (08/2014 - 09/2004)

Related Diseases

1.	Vasculitis (Vasculitides) 06/01/2010 - "Longitudinal changes in proteinase 3 (PR3) gene expression were evaluated using reverse transcription-polymerase chain reaction, and clinical outcomes, including remission status and disease activity, were determined using the Birmingham Vasculitis Activity Score for WG (BVAS-WG). " 11/02/2015 - "Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis." 03/01/2013 - "Different murine models have been used as basis for Proteinase 3 (PR3)-associated vasculitis models, but sufficient reproduction of the human clinical manifestation has failed to this date. " 06/15/2009 - "Some patients with vasculitis have elevated plasma levels of neutrophil-derived proteinase 3 (PR3) and anti-PR3 Abs. " 11/01/2003 - "Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis."
2.	Wegener Granulomatosis (Wegener's Granulomatosis) 09/01/2011 - "A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen." 01/01/2011 - "To analyse whether a specific cytokine pattern is elicited in response to the autoantigen proteinase 3 (PR3) in active Wegener's granulomatosis (WG). " 06/01/2010 - "Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis." 01/01/2010 - "Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis." 09/01/2009 - "Notably, sera containing anti-proteinase 3 (PR3) from patients with Wegener's granulomatosis reacted in MAIGA. "
3.	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 10/01/2007 - "Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. " 01/01/2000 - "T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). " 08/01/2007 - "Furthermore, patients with MPO-ANCA-associated vasculitis (n = 47) were compared with patients with proteinase 3 (PR3)-ANCA associated vasculitis (n = 46). " 07/19/2012 - "These data provide preliminary support for the concept that proteinase 3 ANCA-associated vasculitis and myeloperoxidase ANCA-associated vasculitis are distinct autoimmune syndromes. " 09/01/2011 - "As the proteinase 3 subtype of antineutrophil cytoplasmic antibodies (ANCA) was positive ANCA-associated vasculitis with gastrointestinal, cutaneous and kidney involvement was diagnosed. "
4.	Inflammation 10/29/2009 - "Proteinase 3 (PR3) is an enzyme involved in proteolytic events associated with inflammation. " 09/15/2000 - "Although proteinase 3 (PR3) is known to have the potential to promote inflammation and injure tissues, the biologic forms and function of PR3 in polymorphonuclear neutrophils (PMN) from healthy donors have received little attention. " 06/15/2013 - "Generation of a metabolically stable form of this peptide (CR-AnxA1(2-50)), engineered by substituting a cleavage site shared by human proteinase 3 and neutrophil elastase, yielded an agonist that was resistant to neutrophil-mediated cleavage and displayed enhanced proresolving actions: accelerated resolution of self-limited inflammation and enhanced macrophage efferocytosis after sterile injury, when compared with AnxA1(2-50). " 09/01/2012 - "Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation." 07/01/2008 - "Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin."
5.	Leukemia 03/01/2003 - "Although high-avidity PR1-specific T cells killed CML more effectively than low-avidity T cells, only high-avidity T cells underwent apoptosis when stimulated with high PR1 peptide concentration or when exposed to leukemia that overexpressed proteinase 3. No high-avidity PR1-specific T cells could be identified or expanded from newly diagnosed leukemia patients, whereas low-avidity T cells were readily expanded. " 04/15/2001 - "Myeloblastin can confer factor-independent growth to hematopoietic cells, an early step in leukemia transformation. " 02/15/2000 - "Myeloblastin (MBN) initially was described as involved in proliferation of human leukemia cells. " 10/01/1997 - "These results show that PR1-specific allogeneic T cells preferentially inhibit leukemic CFU-GM based on overexpression of proteinase 3, and that proteinase 3-specific CTL could be used for leukemia-specific adoptive immunotherapy." 10/01/1997 - "Analysis by flow cytometry showed that proteinase 3 was overexpressed in the leukemia targets compared with normal marrow targets (median channel fluorescence 1,399 v 298, P = .009). "

Related Drugs and Biologics

1.	Antineutrophil Cytoplasmic Antibodies (ANCA)
2.	Peroxidase (Myeloperoxidase)
3.	Autoantibodies
4.	Antibodies
5.	Antigens
6.	Myeloblastin (Proteinase 3)
7.	Glucocorticoids
8.	Pancreatic Elastase (Elastase)
9.	Peptide Hydrolases (Proteases)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Stem Cell Transplantation
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Thyroidectomy