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Leukocyte Elastase (Neutrophil Elastase)

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An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

Also Known As:

Neutrophil Elastase; Elastase, Neutrophil; Granulocyte Elastase; Elastase, Granulocyte; Elastase, Leukocyte; Elastase, Lysosomal; Elastase, PMN; Elastase, Polymorphonuclear Leukocyte; Leukocyte Elastase, Polymorphonuclear; Lysosomal Elastase; PMN Elastase; Polymorphonuclear Leukocyte Elastase

Networked: 1606 relevant articles (64 outcomes, 172 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Serine Proteases: 3067
        Serine Endopeptidases
        Pancreatic Elastase: 2886
        Leukocyte Elastase: 1606
        alpha 1-antitrypsin-leukocyte elastase complex: 2
      - Endopeptidases: 212
        Serine Endopeptidases
        Pancreatic Elastase: 2886
        Leukocyte Elastase: 1606
        alpha 1-antitrypsin-leukocyte elastase complex: 2

Experts

1.	Gando, Satoshi: 11 articles (07/2013 - 08/2002)
2.	Hayakawa, Mineji: 10 articles (12/2012 - 08/2002)
3.	McElvaney, Noel G: 9 articles (10/2014 - 06/2003)
4.	Fischer, Bernard M: 9 articles (04/2014 - 04/2003)
5.	Voynow, Judith A: 9 articles (04/2014 - 04/2003)
6.	Sly, Peter D: 8 articles (12/2015 - 07/2009)
7.	Stockley, Robert A: 8 articles (08/2015 - 01/2006)
8.	Sallenave, Jean-Michel: 8 articles (08/2015 - 04/2004)
9.	Kliushnik, T P: 8 articles (01/2014 - 01/2005)
10.	Ishizaka, Akitoshi: 8 articles (10/2011 - 01/2004)

Related Diseases

1.	Acute Lung Injury 08/01/2006 - "Several reports have suggested that the earlier neutrophil elastase inhibitor (NEI) is used, the more dramatically the acute lung injury (ALI) following SIRS can be improved. " 03/01/2002 - "Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor." 02/01/2012 - "The objective of this study was to evaluate the effect of neutrophil elastase on the process of tissue repair after acute lung injury in mice. " 08/01/2004 - "Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study." 06/01/2013 - "Neutrophil elastase (NE) takes part in the pathogenesis of acute lung injury. "
2.	Lung Injury 09/01/1997 - "The drug blocked neutrophil elastase but did not block neutrophil sequestration in the lungs, although the drug improved measurements of lung injury." 01/01/2013 - "Neutrophil elastase inhibitor (NEI) is known to prevent lung injury caused by neutrophil elastase and improve lung function in ALI. " 01/01/2011 - "We developed a neutrophil elastase-specific near-infrared fluorescence imaging agent, which, combined with fluorescence molecular tomographic imaging, allowed us to detect and quantify neutrophil elastase activity in vivo, in real time, and noninvasively in an acute model of lung injury (ALI). " 01/01/2011 - "Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury." 12/01/2008 - "Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters."
3.	Emphysema 12/01/1991 - "4. In vivo, the inhibitory effects of intratracheally administered rALP242 and rALP231 towards human-neutrophil-elastase-induced emphysema were significantly greater than that of recombinant antileucoprotease. " 01/01/1991 - "However, the evidence for involvement of neutrophil elastase in human emphysema is not clear: there are studies using a variety of approaches that weigh on both sides of the question. " 08/01/1989 - "The goal of the present study was to investigate the role of mouse leukocyte elastase (MLE) in the development of emphysema in 1-month-old Tsk mice. " 01/01/1989 - "With the lead provided by the deficiency state, studies aimed at the linkage between alpha 1AT and its target enzyme, neutrophil elastase, have provided useful information about the pathogenesis of emphysema due to cigarette smoking. " 01/01/1988 - "A study was made of the evolution of emphysema and airway injury induced in the lungs of male golden Syrian hamsters by a single intratracheal injection of 350 micrograms human neutrophil elastase (HNE). "
4.	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 03/01/2013 - "Bowel IRI induced a significant increase in serum variables indicative of organ function, cytokine concentrations, neutrophil elastase activity, and lung permeability and edema, which reflected the presence of both systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome. " 01/01/2013 - "Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) in patients with systemic inflammatory response syndrome (SIRS). " 06/01/2010 - "Systemic inflammatory response syndrome score at admission predicts injury severity, organ damage and serum neutrophil elastase production in trauma patients." 06/01/2008 - "Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients." 01/01/2007 - "To determine whether the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) associated with systemic inflammatory response syndrome (SIRS) can be predicted by the plasma neutrophil elastase level. "
5.	Inflammation 07/01/1990 - "After two months, repeat bronchoscopy and bronchoalveolar lavage revealed that bronchial inflammation, as assessed by direct inspection, neutrophilia of bronchial lavage fluid, and the number of alveolar macrophages, the number of alveolar neutrophils and the concentration of neutrophil elastase alpha 1-antiprotease complex in alveolar lavage fluid, had improved significantly. " 01/01/2013 - "In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice. " 05/01/2009 - "However, local synthesis may provide an important mechanism for controlling neutrophil elastase activity at sites of inflammation, and previous studies have shown a marked increase in production after cytokine stimulation. " 06/01/2006 - "To study the nature of endotoxin or lipopolysaccharide (LPS) induced inflammation, we developed a method of quantifying intracellular human neutrophil elastase (HNE) in lysed sputum polymorphs as a means to study the degranulation status of LPS-recruited neutrophils. " 07/31/1995 - "Our studies suggest that plasma and leukocyte elastase are correlated both with etiology and with the severity of the inflammation."

Related Drugs and Biologics

1.	ONO 5046 (sivelestat)
2.	Sodium
3.	urinastatin (MR 20)
4.	Pancreatic Elastase (Elastase)
5.	Interleukin-8 (Interleukin 8)
6.	Smoke
7.	Taurocholic Acid (Sodium Taurocholate)
8.	Caerulein (Ceruletide)
9.	alpha 1-Antitrypsin (alpha 1 Antitrypsin)
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Lung Transplantation
2.	Transplantation (Transplant Recipients)
3.	Investigational Therapies (Experimental Therapy)
4.	Root Planing
5.	Heart Transplantation (Grafting, Heart)