Abstract | BACKGROUND: METHODS: We investigated the modulations of these lipids in both ascitic fluid and plasma specimens obtained from Balb/c mice injected intraperitoneally with Colon-26 cells, as well as the modulations of the lipid contents in the cancer cells obtained from the tumor xenografts. RESULTS: The results were as follows: the levels of sphingosine 1-phosphate were increased, while those of lysophosphatidic acid (LysoPA), especially unsaturated long-chain LysoPA, tended to be increased, in the ascitic fluid. Our findings suggested that ceramides, sphingomyelin, and phosphatidylcholine, their precursors, were supplied by both de novo synthesis and from elsewhere in the body. The levels of lysophosphatidylserine (LysoPS), lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidylethanolamine were also increased in the ascitic fluid, while those of phosphatidylserine (PS), a precursor of LysoPS, were markedly decreased. The levels of arachidonic acid derivatives, especially PGE2-related metabolites, were increased, while the plasma levels of eicosanoids and related mediators were decreased. Comprehensive statistical analyses mainly identified PS in the ascitic fluid and eicosanoids in the plasma as having highly negative predictive values for cancer. CONCLUSIONS: The results proposed many unknown associations of lipid mediators with cancer, underscoring the need for further studies. In particular, the PS/LysoPS pathway could be a novel therapeutic target, and plasma eicosanoids could be useful biomarkers for cancer.
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Authors | Makoto Kurano, Eri Sakai, Yutaka Yatomi |
Journal | Cancer medicine
(Cancer Med)
Vol. 11
Issue 18
Pg. 3491-3507
(09 2022)
ISSN: 2045-7634 [Electronic] United States |
PMID | 35315587
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Ceramides
- Eicosanoids
- Lysophospholipids
- Phosphatidylcholines
- Phosphatidylserines
- Sphingolipids
- Sphingomyelins
- Arachidonic Acid
- Dinoprostone
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Topics |
- Animals
- Arachidonic Acid
- Biomarkers
- Ceramides
- Dinoprostone
- Disease Models, Animal
- Eicosanoids
(metabolism)
- Humans
- Lysophospholipids
(metabolism)
- Mice
- Neoplasms
- Peritonitis
- Phosphatidylcholines
- Phosphatidylserines
- Sphingolipids
- Sphingomyelins
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