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lysophosphatidylserine

stimulates histamine secretion from isolated mast cells in mouse plasma

Networked: 32 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Lysophospholipids: 554
        lysophosphatidylserine: 32

Experts

1.	Yatomi, Yutaka: 8 articles (04/2020 - 10/2014)
2.	Aoki, Junken: 7 articles (04/2020 - 01/2015)
3.	Kurano, Makoto: 7 articles (04/2020 - 01/2015)
4.	Igarashi, Koji: 5 articles (04/2020 - 01/2017)
5.	Ikeda, Hitoshi: 5 articles (01/2020 - 01/2015)
6.	Nishikawa, Masako: 4 articles (04/2020 - 01/2015)
7.	Kano, Kuniyuki: 3 articles (05/2019 - 01/2017)
8.	Shimamoto, Satoshi: 2 articles (04/2020 - 05/2018)
9.	Cravatt, Benjamin F: 2 articles (01/2020 - 01/2013)
10.	Emoto, Shigenobu: 2 articles (05/2019 - 01/2017)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/01/2018 - "The present study is the first study which revealed the association between ATX or PS-PLA1 and melanoma, suggesting the possible involvement of ATX/lysophosphatidic acids or PS-PLA1 /lysophosphatidylserine axis in the pathogenesis of melanoma." 01/01/2021 - "In order to assess the diagnostic value of phosphatidylserine-specific phospholipase A1-alpha (PLA1A), a potent lysophospholipid mediating the production of lysophosphatidylserine, PLA1A mRNA and serum levels were compared in subjects with malignant melanoma (n = 18), primary melanoma (n = 13), and healthy subjects (n = 10). "
2.	Rare Diseases (Rare Disease) 12/01/2022 - "Potentially novel locus-metabolite associations were identified for the region encoding heme transporter FLVCR1 and choline and for lysophosphatidylcholine acetyltransferase LPCAT3 and lysophosphatidylserine 16.0, 18.0, 18.1, and 18.2; these associations are supported by published rare disease and mouse studies. "
3.	Neoplasms (Cancer) 01/01/1988 - "Production of lysophosphatidylserine can be anticipated in pathological situations associated with extensive cell death (tumor growth, graft rejection, burns). " 01/01/2020 - "Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells." 10/01/2014 - "Lysophosphatidylserine (lysoPS) is a type of lysophospholipid mediator, which is involved in allergic conditions and tumor progression. "
4.	Glioma (Gliomas) 09/12/2008 - "Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells." 09/01/2007 - "Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells." 09/12/2008 - "Lysophosphatidylserine (LPS) was found to stimulate intracellular calcium increase in U87 human glioma cells. " 03/01/2008 - "Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells."
5.	Colonic Neoplasms (Colon Cancer) 05/01/2019 - "Our results indicate that, in colon cancer tissues, levels of lysophosphatidylinositol and lysophosphatidylserine were significantly higher ( p = 0.025 and p = 0.01, respectively), whereas levels of lysophosphatidic acid were significantly lower ( p = 0.0019) than in normal tissues. " 03/01/2008 - "Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells." 05/01/2019 - "Fatty acid analysis further showed that 18:0 lysophosphatidylinositol and 18:0 lysophosphatidylserine were the predominant species of lysophospholipids in colon cancer tissues. " 01/01/2020 - "Lysophosphatidylserine (LysoPS) is a lysophospholipid, its generating enzyme, phosphatidylserine-specific phospholipase A1 (PS-PLA1), reportedly plays roles in stomach and colon cancers. "

Related Drugs and Biologics

1.	Lysophospholipids
2.	Lysophosphatidylcholines (Lysophosphatidylcholine)
3.	Heme (Haem)
4.	Choline (Choline Chloride)
5.	Acetyltransferases
6.	Phosphatidylserines
7.	lysophosphatidic acid
8.	Lipids
9.	Lipase (Acid Lipase)
10.	lysophosphatidylinositol

Related Therapies and Procedures

1.	Intraperitoneal Injections