Eicosanoids

A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).

Also Known As:

Networked: 1470 relevant articles (20 outcomes, 105 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Calder, Philip C: 14 articles (04/2015 - 07/2004)
2.	Zeldin, Darryl C: 10 articles (07/2013 - 05/2002)
3.	Dennis, Edward A: 9 articles (11/2014 - 06/2009)
4.	Murphy, Robert C: 8 articles (10/2014 - 09/2008)
5.	Serhan, Charles N: 8 articles (09/2013 - 01/2006)
6.	Stanley, David: 7 articles (01/2011 - 11/2005)
7.	Nicolaou, Anna: 6 articles (09/2015 - 11/2009)
8.	Malik, Kafait U: 6 articles (04/2015 - 11/2010)
9.	Gelb, Michael H: 6 articles (04/2015 - 10/2004)
10.	Das, Undurti N: 6 articles (02/2015 - 01/2009)

Related Diseases

1.	Inflammation 08/01/2013 - "This suggests that fish oil supplementation does have significant benefits in young healthy adults and that specific omega-6-derived eicosanoids can help to further our understanding regarding the beneficial link between omega-3 FA and inflammation." 03/01/2013 - "The aim of the study was to establish bronchial inflammation status and to measure eicosanoids in sputum obtained from active elite athletes. " 08/01/2011 - "Several elegant studies have contributed to the sorting out of the importance of 12-LOX eicosanoids in cytokine-mediated inflammation in pancreatic β cells. " 03/01/1996 - "Rapid quantitation of a large scope of eicosanoids in two models of inflammation: development of an electrospray and tandem mass spectrometry method and application to biological studies." 12/01/1985 - "Several studies have implicated the eicosanoids as mediator substances in different types of UV inflammation. "
2.	Asthma (Bronchial Asthma) 12/01/1999 - "We conclude that induced sputum contains high concentrations of eicosanoids and that sputum LTC(4)/D(4)/E(4) concentrations are significantly greater in subjects with asthma than in normal subjects. " 02/01/2000 - "The aim of this study was assessment of the hypothesis that local production of eicosanoids in the respiratory epithelium in patients with ASA-sensitive asthma/rhinosinusitis (ASARS) differs from that of ASA-tolerant patients with rhinosinusitis (ATRS). " 11/01/2008 - "The value of measurements of eicosanoids in exhaled breath condensate (EBC) for the evaluation of childhood asthma is still inconclusive most likely because of the limited value of the methods used. " 11/01/2008 - "Eicosanoids in exhaled breath condensates in the assessment of childhood asthma." 10/01/2008 - "The pathobiology of asthma is characterized by the production of pro-inflammatory eicosanoids that play important roles in regulating airway responses. "
3.	Atherosclerosis 12/01/2000 - "Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis. " 01/01/2014 - "When active absorption of w-3 and w-6 PNFA is blocked, the cells synthesize by way of compensation non-physiological w-9 eicosanoids which creates the basis of pathogenesis of atherosclerosis, pathology ofautocrine regulation, and paracrine humoral regulation of cell communities and the body. " 09/01/2013 - "These findings provide new insights into the regulation of eicosanoids in atherosclerosis." 09/01/2013 - "Here, we address whether the innate immune signals of nucleotide-binding oligomerization domain-containing protein (NOD) 2 affect eicosanoids metabolism in atherosclerosis. " 09/01/2013 - "NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis."
4.	Neoplasms (Cancer) 11/07/2015 - "In this review, we have evaluated the cancer promoting and anti-cancer roles of different eicosanoids in CRC, and highlighted the most recent literature which describes how those molecules affect not only tumor tissue, but also the tumor microenvironment. " 07/01/2015 - "ω-3 PUFAs have shown to display multiple antitumour actions, while ω-6 PUFAs and its derived eicosanoids promote the effects in cancer cell growth, angiogenesis, and invasion. " 01/01/2013 - "However, cancer progression likely depends on complex changes in multiple eicosanoids produced by cancer cells and by tumor microenvironment and a systematic examination of the spectrum of eicosanoids in cancer has not been performed. " 12/01/2011 - "We discuss the effects of the eicosanoids on tumor cell proliferation, their roles in cell death induction, effects on angiogenesis, migration, invasion and their regulation of the immune response. " 12/01/2011 - "Eicosanoids regulate CRC development and progression, while inhibition of these pathways has generally been shown to inhibit tumor growth/progression. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/01/2000 - "The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed." 11/01/1997 - "This paper contains a brief review of the metabolism and physiological actions of eicosanoids, with a discussion of the potential clinical implications of disturbances in eicosanoid metabolism, particularly in NSAID-induced upper gastrointestinal damage and inflammatory bowel disease. " 06/01/1996 - "Inflammatory bowel disease is associated with increased mucosal release of eicosanoids. " 12/01/1992 - "Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease." 12/01/1990 - "Eicosanoids and inflammatory bowel disease: regulation and prospects for therapy."

Related Drugs and Biologics

1.	Epoprostenol (Prostacyclin)
2.	Arachidonic Acid (Vitamin F)
3.	Cytokines
4.	Platelet Activating Factor
5.	Enzymes
6.	Lipoxins
7.	Aspirin (Acetylsalicylic Acid)
8.	Hydroxyeicosatetraenoic Acids (HETE)
9.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
10.	2,5-dichloro-4-bromophenol (B 2)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Tourniquets
3.	Plasmapheresis
4.	Photochemotherapy (Photodynamic Therapy)
5.	Ligation