Abstract | OBJECTIVE: METHODS: Anthropometric and biochemical examinations were performed in 816 individuals who participated in the Huai'an Diabetes Prevention Program. Serum BCAAs concentrations were measured by hydrophilic interaction chromatography-tandem mass spectrometric method. Oxidative stress was evaluated by malondialdehyde (MDA) as an index of lipid peroxidation and the superoxide dismutase (SOD) activity. RESULTS: A total of 816 participants were divided into three groups: normal glucose metabolism (NGM), prediabetes, and newly-diagnosed diabetes mellitus (NDM). Subjects in NDM group show higher MDA and lower SOD levels than subjects in other groups. L-Val levels positively correlated with MDA levels and negatively with SOD in NDM groups. After adjusting for T2DM risk factors, high L-Val levels were significantly associated with higher BMI, WC, FPG, increased LnTG and decreased HDL-C. L-Val was also independently associated with NDM (OR 1.06, 95% CI 1.02-1.10; P = 0.005). Furthermore, the odds ratios for NDM among participants with high L-Val (≥35.25μg/mL) levels showed a 2.25-fold (95% CI 1.11-4.57; P = 0.024) increase compared to participants with low L-Val (<27.26 μg/mL) levels after adjusting for MDA and confounding factors. CONCLUSION: High serum L-Val levels are independently associated with oxidative stress, thus promoting IR and NDM. Further study should be done to clarify the mechanism.
|
Authors | Wen Hu, Panpan Yang, Zhenzhen Fu, Yongqing Wang, Ying Zhou, Zhengqin Ye, Yingyun Gong, Aijie Huang, Luning Sun, Yang Zhao, Tao Yang, Zhong Li, Xian-Cheng Jiang, Weinan Yu, Hongwen Zhou |
Journal | Diabetes, metabolic syndrome and obesity : targets and therapy
(Diabetes Metab Syndr Obes)
Vol. 15
Pg. 499-509
( 2022)
ISSN: 1178-7007 [Print] New Zealand |
PMID | 35221701
(Publication Type: Journal Article)
|
Copyright | © 2022 Hu et al. |