Abstract | OBJECTIVES: METHODS: RESULTS: In the SSRI group, the baseline GM-CSF level was significantly higher in the remission group than in the non-remission group (p = .022). In the MIR group, the baseline level of TNF-α was significantly higher (p = .039) and IL-2 was lower (p = .032) in the remission group than in the non-remission group. In patients prescribed with MIR, the cut-off values of TNF-α (10.035 pg/mL) and IL-2 (1.170 pg/mL) calculated from the receiver operating characteristic curve suggested that the remission rate, which corresponds to a positive predictive value, could be increased from 31.3% to 60.0% and 50.0%, respectively. For those prescribed with SSRIs, the remission rate was 37.0% and using the cut-off value of GM-CSF (0.205 pg/mL), the remission rate could be almost doubled to 70%. CONCLUSIONS: Our study shows that pre-treatment plasma concentrations of TNF-α, IL-2, and GM-CSF may suggest the predictability of remission by SSRIs or MIR.
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Authors | Kiyokazu Atake, Hikaru Hori, Yuki Kageyama, Yosuke Koshikawa, Ryohei Igata, Hirotaka Tominaga, Asuka Katsuki, Hiroki Bando, Shiho Sakai, Keiichiro Nishida, Yoshiteru Takekita, Tadafumi Kato, Toshihiko Kinoshita, Masaki Kato |
Journal | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
(World J Biol Psychiatry)
Vol. 23
Issue 10
Pg. 785-793
(12 2022)
ISSN: 1814-1412 [Electronic] England |
PMID | 35193470
(Publication Type: Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Granulocyte-Macrophage Colony-Stimulating Factor
- Tumor Necrosis Factor-alpha
- Interleukin-2
- Selective Serotonin Reuptake Inhibitors
- Mirtazapine
- Antidepressive Agents
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Topics |
- Humans
- Cytokines
- Granulocyte-Macrophage Colony-Stimulating Factor
- Tumor Necrosis Factor-alpha
- Interleukin-2
- Selective Serotonin Reuptake Inhibitors
- Mirtazapine
- Antidepressive Agents
(pharmacology, therapeutic use)
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