Biomarkers of Glucose Homeostasis and Inflammation with Risk of Prostate Cancer: A Case-Cohort Study.

Abstract

BACKGROUND:

Few prospective studies have examined biomarkers of glucose homeostasis or inflammation with prostate cancer risk by tumor stage or grade.

METHODS:

We conducted a case-cohort study to examine associations of prediagnosis hemoglobin A1c (HbA1c), C-peptide, and C-reactive protein (CRP) with prostate cancer risk overall and stratified by tumor stage and grade. The study included 390 nonaggressive (T1-2, N0, M0, and Gleason score <8) and 313 aggressive cases (T3-4, or N1, or M1, or Gleason score 8-10) diagnosed after blood draw (1998-2001) and up to 2013, and a random subcohort of 1,303 cancer-free men at blood draw in the Cancer Prevention Study-II Nutrition Cohort. Prentice-weighted Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI).

RESULTS:

In the multivariable-adjusted model without body mass index, HbA1c was inversely associated with nonaggressive prostate cancer (HR per unit increase, 0.89; 95% CI, 0.80-1.00; P = 0.04). Analyses stratified by tumor stage and grade separately showed that HbA1c was inversely associated with low-grade prostate cancer (HR per unit increase, 0.89; 95% CI, 0.80-1.00) and positively associated with high-grade prostate cancer (HR per unit increase, 1.15; 95% CI, 1.01-1.30). C-peptide and CRP were not associated with prostate cancer overall or by stage or grade.

CONCLUSIONS:

The current study suggests that associations of hyperglycemia with prostate cancer may differ by tumor grade and stage.

IMPACT:

Future studies need to examine prostate cancer by tumor stage and grade, and to better understand the role of hyperglycemia in prostate cancer progression.

• Authors: Ying Wang, Susan M Gapstur, Christina C Newton, Marjorie L McCullough, Michael N Pollak, Peter T Campbell
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 31 Issue 4 Pg. 736-743 (04 01 2022) ISSN: 1538-7755 [Electronic] United States
• PMID: 35149581 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: ©2022 American Association for Cancer Research.

Chemical References

• Biomarkers
• Glucose

Topics

• Biomarkers
• Cohort Studies
• Glucose
• Homeostasis
• Humans
• Inflammation (complications)
• Male
• Prospective Studies
• Prostatic Neoplasms (pathology)
• Risk Factors