Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial.

Abstract

OBJECTIVES:

The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis.

METHODS:

Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)-1β and IL-17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR.

RESULTS:

Clinical parameters improved significantly in all groups at 3 and 6 months (p < 0.05). Percentage of sites with probing depth >6 mm was lower in the FMD than Q-SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q-SRP and FM-SRP at both 3 and 6 months after treatment (p < 0.05). The IL-1β levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL-17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05).

CONCLUSIONS:

The FMD treatment appears to offer superior outcome than Q-SRP and could be the first choice for patients with GAgP.

• Authors: Dilek Mamaklıoğlu, Maribasappa Karched, Leyla Kuru, Bahar Kuru, Sirkka Asikainen, Başak Doğan
• Journal: International journal of dental hygiene (Int J Dent Hyg) Vol. 20 Issue 2 Pg. 347-363 (May 2022) ISSN: 1601-5037 [Electronic] England
• PMID: 35143714 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Interleukin-17

Topics

• Aggressive Periodontitis (therapy)
• Bacteria
• Chronic Periodontitis (therapy)
• Dental Scaling
• Gingival Crevicular Fluid
• Humans
• Interleukin-17
• Root Planing