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Chlorhexidine

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A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Also Known As:

Chlorhexidine Acetate; Chlorhexidine Hydrochloride; MK-412A; Novalsan; Sebidin A; Tubulicid; A, Sebidin; Acetate, Chlorhexidine; Hydrochloride, Chlorhexidine; MK 412A; MK412A; 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-

Networked: 1791 relevant articles (221 outcomes, 390 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maki, Dennis G: 9 articles (07/2014 - 08/2002)
2.	Mullany, Luke C: 9 articles (04/2013 - 03/2006)
3.	Gupta, Devanand: 8 articles (07/2015 - 03/2014)
4.	Weinstein, Robert A: 8 articles (02/2013 - 08/2002)
5.	Cosyn, Jan: 8 articles (03/2007 - 07/2005)
6.	Gupta, Rajendra Kumar: 7 articles (07/2015 - 03/2014)
7.	Siqueira, José F: 7 articles (06/2015 - 05/2004)
8.	Darmstadt, Gary L: 7 articles (04/2013 - 03/2006)
9.	Tielsch, James M: 7 articles (01/2013 - 03/2006)
10.	Mermel, Leonard A: 7 articles (03/2011 - 08/2002)

Related Diseases

1.	Infection 03/06/2006 - "Comment on: Johnson PDR, et al. Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. " 03/06/2006 - "Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection." 11/21/2005 - "Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection." 06/15/1996 - "In light of evidence that birth canal exposure to HIV may be a major means of maternal-fetal transmission of the infection, a clinical trial was performed to determine the safety and efficacy of cleansing the birth canal with a cotton pad soaked in 0.25% chlorhexidine. " 03/01/2012 - "Systematic review and meta-analysis of randomized controlled trials and quasi-experimental studies to assess the efficacy of daily bathing with chlorhexidine (CHG) for prevention of healthcare-associated bloodstream infections (BSIs). "
2.	Gingivitis 05/01/2012 - "Chlorhexidine (CHX) as a gold standard chemical agent appears to be the most effective antimicrobial agent for reduction of both plaque and gingivitis. " 06/01/2014 - "The efficacy of herbal mouthwash was equally effective in reducing plaque and gingivitis as compared to chlorhexidine mouthwash and may be considered as a good alternative. " 03/01/2014 - "There was a significant reduction on plaque and gingivitis in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). " 10/01/2012 - "Mouth wash containing Aloe vera showed significant reduction of plaque and gingivitis but when compared with chlorhexidine the effect was less significant. " 03/01/1994 - "In this study, we demonstrate that the use of a foam brush saturated with chlorhexidine was equally effective in measures of plaque levels and gingivitis as was the use of a toothbrush. "
3.	Inflammation 01/01/1982 - "During the 28-day irrigation period with chlorhexidine there was highly significant reduction in periodontal inflammation which was maintained at levels significantly below the baseline values for a further 28-day period without irrigation. " 08/01/2013 - "Chlorehexidine (0.2%) and a phenolic mouth rinse significantly reduced plaque growth and gingival inflammation compared to a placebo mouthrinse, however chlorhexidine rinse was more effective against plaque regrowth than the phenolic rinse. " 09/01/1989 - "The results showed a significant improvement in gingival inflammation and pockets depths in the experimental (chlorhexidine) group." 01/01/1982 - "It is concluded that subgingival irrigation with chlorhexidine is effective in reducing periodontal inflammation and in controlling subgingival plaque. " 01/01/2015 - "The present study was conducted to assess the effectiveness of Terminalia chebula on plaque and gingival inflammation and compare it with the gold standard chlorhexidine (CHX 0.2%) and distilled water as control (placebo). "
4.	Dental Plaque 02/01/1978 - "Two rat plaque-caries studies indicated that a 0.2% chlorhexidine solution topically applied to rat teeth was effective in reducing dental plaque. " 04/01/1974 - "[Evaluation of the efficacy of chlorhexidine in prevention of dental plaque]." 04/01/2014 - "The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it with the bench mark control chlorhexidine and placebo (saline water). " 10/01/2004 - "Clinical studies have demonstrated the considerable effects of chlorhexidine on dental plaque and oral microbiota as well as improvements in indices of oral health. " 10/01/2002 - "To study the effects of an application of chlorhexidine varnish (40%) on dental plaque. "
5.	Chronic Periodontitis 10/01/2015 - "Clinical and antimicrobial efficacy of a controlled-release device containing chlorhexidine in the treatment of chronic periodontitis." 04/01/2013 - "Comparison of the efficacy of chlorhexidine varnish and chip in the treatment of chronic periodontitis." 02/01/2011 - " To evaluate the efficacy of a 2-week administration of a 0.1% chlorhexidine mouthwash in the short-term treatment of chronic periodontitis patients and the impact of this product when administered twice by pocket irrigation. " 06/01/2014 - "Chlorhexidine chip in the treatment of chronic periodontitis - a clinical study." 08/01/2013 - "In this study--a preliminary case series with small sample size and short follow-up--the adjunctive use of chlorhexidine (CHX) to SRP resulted in clinical and microbiological benefits in the treatment for generalized chronic periodontitis. "

Related Drugs and Biologics

1.	Povidone-Iodine (Betadine)
2.	Silver Sulfadiazine (SSD)
3.	xanthan gum (xanthan)
4.	Triclosan (pHisoHex)
5.	Mouthwashes
6.	Metronidazole (Metric)
7.	Dentifrices (Dentifrice)
8.	Listerine
9.	Fluorides
10.	Hydrogen Peroxide (Hydroperoxide)

Related Therapies and Procedures

1.	Catheters
2.	Root Planing
3.	Drug Therapy (Chemotherapy)
4.	Oral Hygiene (Dental Hygiene)
5.	Intensive Care (Surgical Intensive Care)