Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation.

Abstract

Alzheimer's disease (AD), the most common form of neurodegenerative dementia among the older population, is associated with acute or chronic inflammation. As a nonsteroidal anti-inflammatory drug, aspirin has recently been widely studied in the prevention and treatment of neurodegenerative diseases. However, there is a controversy about the efficacy as well as the adverse effects of aspirin. 10-Hydroxydecanoic acid (10-HDAA) is a characteristic fatty acid found in the honey bee product royal jelly. In this study, we found that 10-HDAA attenuated the activation of the NF-κB pathway, then targeted Ptgs-1/2, the well-known target of aspirin. Hence, combined therapy of 10-HDAA and aspirin was conducted. In vitro assays suggested that this combinatory group alleviated LPS-induced inflammation in BV-2 cells, as assessed by the downregulation of nitric oxide, COX-2, and IL-6 compared to 10-HDAA or aspirin treatment alone. In vivo assays showed that the combined treatment synergistically inhibited the overactivation of glial cells and decreased the levels of pro-inflammatory mediators. Moreover, 10-HDAA alleviated the adverse effects of aspirin on gastrointestinal injuries and microbiota dysbiosis. The Morris water maze test indicated that neither 10-HDAA nor aspirin effectively improved LPS-induced memory dysfunction, but the combined therapy showed synergistic effects. Altogether, our findings support 10-HDAA and aspirin combinatory therapy as the basis for future therapeutics for AD and other neuroinflammation-related diseases with minimal adverse effects.

• Authors: Mengmeng You, Kangli Wang, Yongming Pan, Lingchen Tao, Quanxin Ma, Guozhi Zhang, Fuliang Hu
• Journal: Food & function (Food Funct) Vol. 13 Issue 4 Pg. 2336-2353 (Feb 21 2022) ISSN: 2042-650X [Electronic] England
• PMID: 35142767 (Publication Type: Journal Article)

Chemical References

• 10-hydroxydecanoic acid
• Decanoic Acids
• Fatty Acids
• Neuroprotective Agents
• royal jelly
• Aspirin

Topics

• Administration, Oral
• Animals
• Aspirin (administration & dosage, chemistry, pharmacology)
• Astrocytes (drug effects)
• Bees
• Decanoic Acids (administration & dosage, chemistry, pharmacology)
• Disease Models, Animal
• Drug Synergism
• Fatty Acids
• Functional Food
• Male
• Maze Learning (drug effects)
• Memory Disorders (prevention & control)
• Mice
• Mice, Inbred C57BL
• Neuroinflammatory Diseases (prevention & control)
• Neuroprotective Agents (administration & dosage, chemistry, pharmacology)
• Random Allocation