Abstract | BACKGROUND: This study retrospectively analyzed and evaluated the potential correlations of serum calcium, serum phosphorus, and calcium- phosphorus product (Ca-P product) with the incidence of osteoporotic vertebral compression fractures (OVCFs), with the aim of exploring whether the Ca-P product can be used as a serological indicator to predict the risk of OVCFs. METHODS: RESULTS:
Albumin, serum calcium, serum phosphorus, Ca-P product, corrected serum calcium and corrected Ca-P product were lower in the OVCF group than in the non-OVCF group (P < 0.05). Multivariate logistic regression analysis showed that low values of serum calcium, serum phosphorus, Ca-P product, corrected blood calcium, and corrected Ca-P product can all be risk factors for OVCF. The ROC curve showed that the Ca-P product and corrected Ca-P product were effective in predicting the risk of OVCFs. The predictive value of the Ca-P product was the best; the cutoff point was 29.88, the sensitivity was 0.72 and the specificity was 0.62. The cutoff point of the corrected Ca-P product was 30.50, the sensitivity was 0.74, and the specificity was 0.62. CONCLUSION: The Ca-P product and corrected Ca-P product can be used as serological indicators to predict the risk of OVCFs in elderly individuals. Early clinical interventions targeting this risk factor can further reduce the risk of OVCFs. Also, timely and regular testing of the serum calcium and phosphorus level is recommended and encouraged for this group of people.
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Authors | Pu Ying, Mingjia Gu, Xiaowei Jiang, Yue Xu, Lu Tong, Yi Xue, Qiang Wang, Zhihui Huang, Wenge Ding, Xiaoyu Dai |
Journal | Journal of orthopaedic surgery and research
(J Orthop Surg Res)
Vol. 17
Issue 1
Pg. 57
(Jan 29 2022)
ISSN: 1749-799X [Electronic] England |
PMID | 35093148
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2022. The Author(s). |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Calcium
(blood)
- Female
- Fractures, Compression
(blood)
- Humans
- Incidence
- Male
- Osteoporotic Fractures
(blood, epidemiology, etiology)
- Phosphorus
(blood)
- Retrospective Studies
- Risk Factors
- Spinal Fractures
(blood, diagnostic imaging, epidemiology)
- Treatment Outcome
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