2-Aminoethoxydiphenyl borate ameliorates functional and structural abnormalities in cisplatin-induced peripheral neuropathy.

Abstract

AIM OF THE STUDY:

Cisplatin is a platinum-derived chemotherapeutic agent commonly used in the treatment of various tumors. Ototoxicity, nephrotoxicity, and peripheral neuropathy are the most common side effects of this drug. 2-Aminoethoxydiphenyl borate (2-APB), boron- containing compound, has some protective effects against various tissue damage. The present study aimed to investigate the potential protective effects of 2-APB on in vitro and in vivo cisplatin-induced neurotoxicity.

MATERIALS AND METHODS:

MTT assay was used to determine cell viability in DRG cells. Peripheral neuropathy was induced in forty male Sprague-Dawley rats (200-250g) by administering cisplatin (3 mg/kg/week) intraperitoneally (i.p) for five weeks. 2-APB (2, 4, and 8 mg/kg, i.p) was administered. Mechanical allodynia, thermal hyperalgesia, cold allodynia, mechanical stimuli, motor coordination, and locomotor activity tests were performed. DRG cells and sciatic nerves were analyzed histologically. NGF, BDNF, TNF-α, GSH, MDA, and LDH levels were investigated in rat DRG tissue homogenates.

RESULTS:

Our results revealed that 2-APB ameliorated cisplatin-induced neurotoxicity by improving mechanical and cold allodynia and motor coordination impairment. It also reduced cisplatin-induced structural toxicity in peripheral tissues.

CONCLUSION:

These findings demonstrated that 2-APB could be considered as a potential therapeutic strategy for the treatment of cisplatin-induced peripheral neuropathy.

• Authors: Ezgi Eroglu, Cigdem Cengelli Unel, Nusin Harmanci, Kevser Erol, Neziha Senem Ari, Orhan Ozatik
• Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (J Trace Elem Med Biol) Vol. 70 Pg. 126909 (Mar 2022) ISSN: 1878-3252 [Electronic] Germany
• PMID: 34902678 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier GmbH. All rights reserved.

Chemical References

• Antineoplastic Agents
• Boron Compounds
• 2-aminoethoxydiphenyl borate
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects)
• Boron Compounds (adverse effects)
• Cisplatin (adverse effects)
• Male
• Peripheral Nervous System Diseases (chemically induced, drug therapy)
• Rats
• Rats, Sprague-Dawley