[The role of adenine nucleotide and its metabolites in regulating the homeostasis of glucose and lipid metabolism].

Abstract

Glucose and lipid metabolism is the most fundamental metabolic activity of higher organisms. This process is affected by both genetic polymorphisms and environmental factors. Excessive uptake and accumulation of lipids lead to obesity and disorder of glucose metabolic homeostasis characterized by insulin resistance and hyperglycemia, suggesting that the cross-regulation between lipid and glucose metabolism happens precisely at organ, cellular and molecular levels by known mechanisms. Adenine nucleotides and their metabolites have emerged as mediators in the mutual regulation of glucose and lipid metabolism. This review summarizes the roles of purinergic signaling induced by fatty acids in glucose metabolism and the development of type 2 diabetes.

• Authors: Wen-Hao Ge, Jun-Hao Liu, Yun-Xia Yang, Yang Zhao, Zhao Ding, Jian-Fa Zhang
• Journal: Sheng li xue bao : [Acta physiologica Sinica] (Sheng Li Xue Bao) Vol. 73 Issue 5 Pg. 707-722 (Oct 25 2021) ISSN: 0371-0874 [Print] China
• PMID: 34708228 (Publication Type: Journal Article, Review)

Chemical References

• Adenine Nucleotides
• Glucose

Topics

• Adenine Nucleotides
• Diabetes Mellitus, Type 2
• Glucose
• Homeostasis
• Humans
• Insulin Resistance
• Lipid Metabolism