Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin.

Abstract	Special electromagnetic field-treated water (SEW) and far-infrared radiation (FIR) can reduce acute respiratory distress syndrome (ARDS) in rats inflicted by lipopolysaccharides (LPSs). However, little is known about its underlying molecular mechanism. Differentially expressed proteins (DEPs) of SEW and FIR interventions were obtained from a proteomics database. A total of 89 DEPs were identified. Enrichment analysis of DEPs was performed using the Database for Annotation, Visualization, and Integrated Discovery. These DEPs were associated with the responses to LPSs, acute inflammation, extracellular exosomes, glucocorticoids, and electrical stimuli. The protein-protein interaction network was set up using the STRING database. Modular analysis was performed using MCODE in the Cytoscape software. Proteins Haptoglobin, Apolipoprotein B, Transthyretin, and Fatty acid binding protein 1 were among the core networks. A tail vein injection of LPS was used to establish the rat model with ARDS. Parallel reaction monitoring confirmed Hp protein expression. Inflammatory pathway factors were detected using an enzyme-linked immunosorbent assay. This indicates that SEW and FIR can be considered as potential clinical treatment methods for ARDS treatment and that their functional mechanisms are related to the ability of alleviating lung inflammation through Hp protein adjustment.
Authors	Changyong Luo, Yan Li, Xu Liang, Yifan Chen, Qiao Zou, Yurong Kong, Zhengguang Guo, Wei Sun, Xin Wang
Journal	Bioengineered (Bioengineered) Vol. 12 Issue 1 Pg. 6808-6820 (12 2021) ISSN: 2165-5987 [Electronic] United States
PMID	34519633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Haptoglobins Lipopolysaccharides Water
Topics	Animals Disease Models, Animal Electromagnetic Fields Haptoglobins (metabolism) Infrared Rays Lipopolysaccharides (adverse effects) Lung (drug effects, metabolism, pathology, radiation effects) Male Rats Rats, Sprague-Dawley Respiratory Distress Syndrome (chemically induced, metabolism) Water (chemistry, pharmacology)

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