Abstract | BACKGROUND:
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and intractable complication in chemotherapy-receiving patients. Insulin-like growth factor-1 (IGF-1) is a popular neurotrophin with various functions, such as maintaining neuronal survival and synaptic functioning in the central nervous system. Therefore, we hypothesized that the IGF-1 signaling pathway could be a candidate target for treating CIPN. METHODS: RESULTS:
IGF-1 protein expression decreased significantly in the spinal cord on D3 and D10 (the 3rd and 10th days after beginning oxaliplatin chemotherapy) and was co-localized with astrocytes primarily in the lumbar spinal cord, whereas IGF1R was predominantly expressed on neurons. Both intrathecally- and intraperitoneally-administered rIGF-1 relieved the chemotherapy-induced pain-like behavior and reduced IL-17A, TNF-α, and CGRP protein expressions in the spinal cord. CONCLUSION: Our results indicate a vital role for IGF-1 signaling in CIPN. Targeting IGF-1 signaling could be a potent therapeutic strategy for treating CIPN in clinical settings.
|
Authors | Yue Le, Xin Chen, Long Wang, Wan-You He, Jian He, Qing-Ming Xiong, Yun-Hua Wang, Lei Zhang, Xue-Qin Zheng, Han-Bing Wang |
Journal | Brain research bulletin
(Brain Res Bull)
Vol. 175
Pg. 205-212
(10 2021)
ISSN: 1873-2747 [Electronic] United States |
PMID | 34333050
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Cytokines
- insulin-like growth factor-1, mouse
- Oxaliplatin
- Insulin-Like Growth Factor I
- Receptor, IGF Type 1
|
Topics |
- Animals
- Antineoplastic Agents
(toxicity)
- Astrocytes
(drug effects, metabolism)
- Cytokines
(metabolism)
- Injections, Spinal
- Insulin-Like Growth Factor I
(biosynthesis, pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
- Neurons
- Oxaliplatin
(toxicity)
- Pain
(psychology)
- Peripheral Nervous System Diseases
(chemically induced, psychology)
- Receptor, IGF Type 1
(drug effects)
- Signal Transduction
(drug effects)
- Spinal Cord
(metabolism)
|