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Hydroxychloroquine alleviates the neurotoxicity induced by anti-ribosomal P antibodies.

Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide spectrum of autoantibodies, among which anti-ribosomal P (anti-P) antibodies are considered to be closely related to the neuropsychiatric SLE (NPSLE). Hydroxychloroquine (HCQ) has been proven to be effective against a variety of autoimmune diseases and is an essential drug for the treatment of SLE. In this study, we investigated the effects of anti-ribosomal P (anti-P) antibodies on neural cells and determined whether hydroxychloroquine (HCQ) influenced the anti-P antibodies-induced changes. The results showed that the binding of anti-P antibodies with mouse neuroblastoma- 2a (N2a) cells and rat primary neurons resulted in elevated intracellular calcium levels, inducing decreased cell viability and cell apoptosis. These inhibitory effects were alleviated by HCQ in a concentration-dependent manner by reducing the intracellular calcium levels and modulating the expression of apoptotic proteins. In summary, our study demonstrates that anti-P antibodies induce neural cell damage. HCQ could ease the damage effects and may play a neuroprotective role in NPSLE.
AuthorsXinnan Zhao, Pingting Yang
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 358 Pg. 577648 (09 15 2021) ISSN: 1872-8421 [Electronic] Netherlands
PMID34229206 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2021 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-ribosomal P protein autoantibodies
  • Antibodies, Antinuclear
  • Enzyme Inhibitors
  • Hydroxychloroquine
Topics
  • Animals
  • Antibodies, Antinuclear (immunology, metabolism, toxicity)
  • Cell Line, Tumor
  • Cell Survival (drug effects, physiology)
  • Cells, Cultured
  • Enzyme Inhibitors (pharmacology)
  • Hippocampus (cytology, metabolism)
  • Humans
  • Hydroxychloroquine (pharmacology)
  • Lupus Erythematosus, Systemic (immunology, metabolism)
  • Mice
  • Rabbits
  • Rats

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