Abstract | OBJECTIVE: To investigate the efficacy and mechanism of the Qingre Huayu Fang () on atherosclerotic vulnerable plaque in apolipoprotein E (ApoE) knockout mice through the ubiquitin proteasome pathway. METHODS: Sixty 8-week-old C57BL/6J ApoE knockout mice were fed a high-fat for 12 weeks and randomly divided into four treatment groups (n = 15 each): high-fat control, bortezomib (a proteasome inhibitor), bortezomib combined with Qingre Huayu Fang, and Qingre Huayu Fang alone. Aortic sections were examined for plaque development, inflammatory cell infiltration, type Ⅰ/Ⅲ collagen expression and immunohistochemical staining of CD40L, nuclear factor-kappa B (NF-κB)/P65 and ubiquitin. RESULTS: CONCLUSION:
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Authors | Jun Pang, Wen-Li Cheng, Jingbing Peng, Hong Li, Qiang Wu, Ling Li, Cheng-Ming Liu, Wei Liu, Jing Huang |
Journal | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
(J Tradit Chin Med)
Vol. 41
Issue 3
Pg. 432-437
(06 2021)
ISSN: 2589-451X [Electronic] China |
PMID | 34114401
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- Proteasome Endopeptidase Complex
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Topics |
- Animals
- Apolipoproteins E
(genetics)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Plaque, Atherosclerotic
(drug therapy, genetics)
- Proteasome Endopeptidase Complex
(genetics)
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