[Research progress of curcumin in the treatment of osteoarthritis].

Abstract

Curcumin is the main active component of Curcuma longa,which has a variety of biological activities and pharmacological properties.Clinical studies have shown that curcumin and its derivatives can improve the pathological progress of osteoarthritis. The mechanism mainly includes enhancing the activity of antioxidant enzymes,inhibiting oxidative stress,and protecting cartilage from damage;blocking inflammation-related signal pathways,reducing the production and activity of inflammatory factors,and reducing inflammation;playing the role of immune regulation by interacting with immune cells and immune molecules;slowing down osteoarthritis by inhibiting chondrocyte apoptosis and enhancing cartilage protection. Curcumin is one of the potential drugs for the treatment of osteoarthritis.

• Authors: X Y Shen, Y Li, Z Zhang
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 59 Issue 6 Pg. 554-557 (Jun 01 2021) ISSN: 0529-5815 [Print] China
• PMID: 34102742 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Curcumin

Topics

• Antioxidants
• Chondrocytes
• Curcumin (therapeutic use)
• Humans
• Osteoarthritis (drug therapy)
• Oxidative Stress