Fermented rice bran (FRB) is known to protect mice intestines against
dextran sodium sulfate (DSS)-induced
inflammation; however, the restoration of post-
colitis intestinal homeostasis using FRB supplementation is currently undocumented. In this study, we observed the effects of dietary FRB supplementation on intestinal restoration and the development of
fibrosis after DSS-induced
colitis. DSS (1.5%) was introduced in the
drinking water of mice for 5 days. Eight mice were sacrificed immediately after the DSS treatment ended. The remaining mice were divided into three groups, comprising the following diets: control, 10% rice bran (RB), and 10% FRB-supplemented. Diet treatment was continued for 2 weeks, after which half the population of mice from each group was sacrificed. The experiment was continued for another 3 weeks before the remaining mice were sacrificed. FRB supplementation could reduce the general observation of
colitis and production of intestinal pro-inflammatory
cytokines. FRB also increased intestinal
mRNA levels of anti-inflammatory
cytokine, tight junction, and anti-microbial
proteins. Furthermore, FRB supplementation suppressed markers of intestinal
fibrosis. This effect might have been achieved via the canonical Smad2/3 activation and the non-canonical pathway of Tgf-β activity. These results suggest that FRB may be an alternative therapeutic agent against
inflammation-induced intestinal
fibrosis.