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Dextrans (Dextran)

A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.

Also Known As:

Dextran; Promit; Dextran 40; Dextran 40000; Dextran 70; Dextran 75; Dextran 80; Dextran B-1355; Dextran B-1355-S; Dextran B1355; Dextran B512; Dextran M 70; Dextran T 70; Dextran T-40; Dextran T-500; Hemodex; Hyskon; Infukoll; Macrodex; Polyglucin; Rheodextran; Rheoisodex; Rheomacrodex; Rheopolyglucin; Rondex; Saviosol; Dextran B 1355; Dextran B 1355 S; Dextran T 40; Dextran T 500

Networked: 5008 relevant articles (278 outcomes, 569 trials/studies)

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Drug Context: Research Results

Experts

1.	Tanaka, Takuji: 21 articles (08/2014 - 10/2003)
2.	Merlin, Didier: 20 articles (07/2014 - 07/2005)
3.	Sitaraman, Shanthi V: 15 articles (05/2013 - 12/2005)
4.	Granger, D Neil: 14 articles (02/2014 - 12/2002)
5.	Laroui, Hamed: 11 articles (07/2014 - 01/2009)
6.	Gewirtz, Andrew T: 11 articles (05/2014 - 05/2002)
7.	Sugie, Shigeyuki: 11 articles (01/2012 - 11/2003)
8.	Pothoulakis, Charalabos: 10 articles (10/2015 - 08/2008)
9.	Kohno, Hiroyuki: 10 articles (11/2007 - 11/2003)
10.	Suzuki, Rikako: 10 articles (11/2007 - 11/2003)

Related Diseases

1.	Colitis 01/01/2014 - "Mouse colitis was induced by oral 2% dextran-sulphate (DSS) for 10 days. " 01/01/2014 - "denudation of the mucus layer associated with oral dextran sulphate in rodents, induces colitis. " 11/01/2013 - "Feces for bile acid analysis were collected after 3-wk feeding, followed by induction of dextran DSS colitis (2 d 5% DSS in drinking water + 2 d tap water). " 11/01/2007 - "AQP3 null mice given dextran sulphate developed severe colitis after 3 days, with colonic haemorrhage, marked epithelial cell loss and death. " 08/01/2004 - "Wild-type mice and mice heterozygous and homozygous for CFTR mutations were given dextran orally for 14 days to induce colitis. "
2.	Neoplasms (Cancer) 06/01/1993 - "Dextran hepatic artery embolization was very effective for not only main tumor but also daughter foci or metastatic nodules, as was confirmed histologically in 8 cases. " 09/01/2014 - "Cytotoxicity studies on human cervical cancer (HeLa) cell line showed non-toxic and biocompatible nature of dextran. " 11/05/2012 - "An intriguing initial result is reported that in vitro studies of DOX-loaded dextran-nanoparticles (compared to free DOX) revealed an increased differential toxicity toward a cancer cell line when compared to a normal cell line. " 12/01/2001 - "We found in a previous study that K(AV) of dextran in tumor tissues decreased sharply when the molecular weight (MW) of dextran was increased from 40,000 to 70,000. " 09/01/2000 - "The 188Re labeled dextran presented in this study provides a template with therapeutic and diagnostic potential in nuclear oncology, either alone for local treatment or as a backbone in a tumor specific conjugate for systemic treatment."
3.	Inflammation 06/01/2004 - "This study demonstrates that Tc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA." 04/01/2006 - "The present study examined the hypothesis that hypertonic saline dextran (HSD), given after an initial insult, attenuates exaggerated inflammation that occurs with a second insult. " 01/01/1972 - "Some studies on acute inflammation induced by dextran in the mouse." 07/01/2015 - "However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (P<0.05) in the SH group at days 7 and 28, compared to the HPMC/dextran group. " 03/01/2013 - "To noninvasively assess plaque inflammation with dextran nanoparticle (DNP)-facilitated hybrid positron emission tomography/magnetic resonance imaging (PET/MRI). "
4.	Hemorrhage 09/01/1992 - "The volume of hemorrhage and the mortality rate in hypertonic saline/dextran-treated animals were significantly greater than in the nonresuscitated controls (1,340 +/- 230 mL versus 783 +/- 85 mL and five of eight versus zero of eight, respectively; P less than .05). " 04/15/1978 - "In patients receiving dextran there was no greater median operative blood loss but there was a significantly greater incidence of postoperative bleeding complications." 09/01/1969 - "The relative efficacy of whole blood, saline and dextran 110 in restoring renal cortical blood-flow following hemorrhage." 12/01/1989 - "These data show that HSD ameliorates the effects of hemorrhage on cardiovascular and renal function and suggest that plasma clearance of dextran may be affected by hemorrhage." 10/01/1986 - "We evaluated the efficacy of a small-volume infusion of 7.5% NaCl in 6% Dextran 70 as a treatment modality for an otherwise lethal hemorrhage in swine. "
5.	Thrombosis (Thrombus) 09/01/2008 - "Thrombi formed ex vivo from the intraoperative blood samples from the dextran-treated patients exhibited significantly greater fibrinolysis vs preoperative samples, seen both as a significantly greater percentage reduction in thrombus weight (from 34.7% to 70.6% reduction) and as an 175% increase in the release of fluorescence (P < .05). " 07/01/1985 - "The efficacy of dextran 40 in preventing early postoperative thrombosis following difficult lower extremity bypass." 11/01/1984 - "The efficacy of dextran 40 in preventing early postoperative thrombosis following difficult lower extremity bypass." 09/01/1993 - "As a marked diminution in microvascular thrombosis was demonstrated at a clinically relevant dose, the continued use of intravenous dextran 40 in clinical microsurgery is supported by this study." 05/01/1971 - "[Trial prevention of thrombosis with low molecular weight dextran during selective arteriography]."

Related Drugs and Biologics

1.	sodium sulfate (sodium bisulfate)
2.	Sodium
3.	Dextrans (Dextran)
4.	Iron
5.	Heparin (Liquaemin)
6.	Azoxymethane
7.	Carrageenan
8.	Sodium Chloride (Saline Solution)
9.	Polymers
10.	Histamine (Histamine Dihydrochloride)

Related Therapies and Procedures

1.	Resuscitation
2.	Hip Replacement Arthroplasty (Total Hip Replacement)
3.	Hemodilution
4.	Oral Administration
5.	Renal Dialysis (Hemodialysis)