IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery.

Abstract

Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels after biliopancreatic diversion with duodenal switch (BPD-DS) than after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This increase is closely associated with insulin sensitization. In mice and rats, BPD-DS and RYGB operations also increase circulating IGFBP-2 levels, which are not affected by SG or caloric restriction. In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.

• Authors: Justine Faramia, Zheng Hao, Michael B Mumphrey, R Leigh Townsend, Stéphanie Miard, Anne-Marie Carreau, Mélanie Nadeau, Frédérique Frisch, Elena-Dana Baraboi, Thomas Grenier-Larouche, Christophe Noll, Meng Li, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Christopher D Morrison, Heike Münzberg, Denis Richard, André C Carpentier, André Tchernof, Hans-Rudolf Berthoud, Frédéric Picard
• Journal: Cell reports. Medicine (Cell Rep Med) Vol. 2 Issue 4 Pg. 100248 (04 20 2021) ISSN: 2666-3791 [Electronic] United States
• PMID: 33948578 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 The Author(s).

Chemical References

• IGFBP2 protein, human
• Insulin-Like Growth Factor Binding Protein 2

Topics

• Animals
• Bariatric Surgery (methods)
• Biliopancreatic Diversion (methods)
• Biochemical Phenomena (physiology)
• Gastrectomy (methods)
• Gastric Bypass (methods)
• Humans
• Insulin-Like Growth Factor Binding Protein 2 (metabolism)
• Mice
• Obesity (surgery)
• Obesity, Morbid (metabolism, surgery)