Abstract | BACKGROUND: METHODS: We conducted a meta-analysis using individual patient data (IPD) to investigate the average efficacy of nab-PTX-containing regimens as neoadjuvant chemotherapy for operable breast cancer. IPD were provided by principal investigators who agreed to participate. The primary endpoint was pathological complete response (pCR) rate of each breast cancer subtype. RESULTS: We analyzed the data of 16 studies involving 753 patients. The overall crude frequencies of pCR (ypT0 ypN0, ypT0/is ypN0, and ypT0/is ypNX) were 18.1, 26.0, and 28.6%, respectively. Specifically, the frequencies were 6.7, 10.2, and 13.4% for luminal (n = 343); 40.5, 63.5, and 68.9% for human epidermal growth factor receptor 2 (HER2)-rich, (n = 74); 21.9, 40.6, and 42.7% for luminal/HER2 (n = 96); and 26.3, 31.5, and 32.3% for triple-negative breast cancers (TNBC) (n = 232). The multivariate analyses indicated that HER2 positivity, TNBC, high Ki-67, high nuclear grade, and weekly nab-PTX administration were significantly associated with the pCR. The proportion of hematological toxicities ( neutropenia (39.7%) and leukopenia (22.5%)), peripheral sensory neuropathy (9.7%), myalgia (5.7%), and arthralgia (4.7%) was higher than grade 3 adverse events, but most patients recovered. CONCLUSIONS: Nab-PTX is a safe and acceptable chemotherapeutic agent in neoadjuvant settings, particularly for aggressive cancers. UMIN-CTR#: UMIN000028774.
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Authors | Manabu Futamura, Mari Oba, Norikazu Masuda, Hiroko Bando, Morihito Okada, Yutaka Yamamoto, Takanori Kin, Toshiaki Saeki, Takeshi Nagashima, Takashi Kuwayama, Uhi Toh, Akira Hirano, Masafumi Inokuchi, Kazuhiko Yamagami, Yutaka Mizuno, Yasuyuki Kojima, Takahiro Nakayama, Hiroyuki Yasojima, Shinji Ohno |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 28
Issue 5
Pg. 1023-1037
(Sep 2021)
ISSN: 1880-4233 [Electronic] Japan |
PMID | 33811599
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Albumin-Bound Paclitaxel
- Anthracyclines
- Antineoplastic Agents
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Albumin-Bound Paclitaxel
(administration & dosage, adverse effects)
- Anthracyclines
(therapeutic use)
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, pathology)
- Chemotherapy, Adjuvant
(methods)
- Female
- Humans
- Middle Aged
- Neoadjuvant Therapy
(methods)
- Receptor, ErbB-2
- Triple Negative Breast Neoplasms
(drug therapy)
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