Blimp-1 inhibits Th9 cell differentiation and attenuates diabetic coronary heart disease.
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| Abstract |
Diabetic coronary heart disease (DM-CHD) poses a major threat to the world. The newly described T cell subset-Th9 cells and related cytokine interleukin (IL)-9 play important roles in the pathogenesis of diabetes and atherosclerosis. B lymphocyte-induced maturation protein 1 (Blimp-1) has been indicated to negatively regulate Th9 development in allergic asthma, but its role in DM-CHD remains unclear. Hence, this study was designed to investigate the role of Blimp-1 in DM-CHD and to elucidate whether the mechanism was associated with regulation of Th9 cell differentiation. Our results showed that serum Blimp-1 mRNA level was decreased whereas proportion of Th9 cells (IL-9+ CD4+ T cells) and serum level of Th9-related IL-9 were increased in DM-CHD patients. Furthermore, serum Blimp-1 mRNA level was negatively correlated with IL-9 level in DM-CHD patients. Importantly, administration of lentiviruses expressing Blimp-1 (LV-Blimp-1) significantly inhibited Th9 cell differentiation and alleviated the severity of atherosclerotic lesions in the aorta and coronary artery, dyslipidemia, inflammation, vascular endothelial dysfunction, and oxidative stress in DM-CHD model rats. Collectively, Blimp-1 exerts a protective effect in DM-CHD rats and the mechanism might involve inhibition of Th9 cell differentiation.
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| Authors | Haiyan Chen, Fangyuan Gao, Yi Bao, Jiaoyang Zheng, Liangliang Sun, Wei Tang, Junjie Zou, Yongquan Shi |
| Journal | International immunopharmacology (Int Immunopharmacol) Vol. 95 Pg. 107510 (Jun 2021) ISSN: 1878-1705 [Electronic] Netherlands |
| PMID | 33706054 (Publication Type: Journal Article) |
| Copyright | Copyright © 2021. Published by Elsevier B.V. |
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