Abstract | BACKGROUND & AIMS: METHODS: Six heterozygotes for HFI (hHFI) and 6 controls (Ctrl) were studied in a randomized, controlled, crossover trial. Participants ingested two identical test meals containing 0.7 g kg-1 glucose and 0.7 g kg-1 fructose according to a cross-over design, once after a 7-day on a low fructose diet (LoFruD, <10 g/d) and on another occasion after 7 days on a high fructose diet (HiFruD, 1.4 g kg-1 day-1 fructose + 0.1 g kg-1 day-1 glucose). Uric acid, glucose, and insulin concentrations were monitored in fasting conditions and over 2 h postprandial, and insulin resistance indexes were calculated. RESULTS: CONCLUSIONS: Seven days of HiFruD increased fasting uric acid and slightly reduced fasting HOMA index in both groups. In contrast, HiFruD increased postprandial uric acid, insulin concentration and HIRI in hHFI only, suggesting that heterozygosity for pathogenic Aldolase B variants may confer an increased susceptibility to the effects of dietary fructose on uric acid and hepatic insulin sensitivity. This trial was registered at the U.S. Clinical Trials Registry as NCT03545581.
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Authors | François-Guillaume Debray, Kevin Seyssel, Marjorie Fadeur, Luc Tappy, Nicolas Paquot, Christel Tran |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 40
Issue 6
Pg. 4246-4254
(06 2021)
ISSN: 1532-1983 [Electronic] England |
PMID | 33551217
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Blood Glucose
- Insulin
- Uric Acid
- Fructose
- Fructose-Bisphosphate Aldolase
- Glucose
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Cross-Over Studies
- Diet, Carbohydrate Loading
(adverse effects, methods)
- Fasting
(blood)
- Female
- Fructose
(administration & dosage, adverse effects)
- Fructose Intolerance
(blood, genetics)
- Fructose-Bisphosphate Aldolase
(genetics)
- Glucose
(administration & dosage, adverse effects)
- Heterozygote
- Humans
- Hyperuricemia
(etiology, genetics)
- Insulin
(blood)
- Insulin Resistance
(genetics)
- Liver
(metabolism)
- Male
- Meals
(physiology)
- Metabolic Syndrome
(blood, genetics)
- Postprandial Period
- Uric Acid
(blood)
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