Acute cigarette smoke exposure causes lung injury in rabbits treated with ibuprofen.

Abstract

We studied lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (99mTcDTPA), plasma concentrations of 6-keto-PGF1 alpha and thromboxane B2, and pulmonary edema as indices of lung injury in rabbits exposed to cigarette smoke (CSE). Forty-six rabbits were randomly assigned to 4 groups: control sham smoke exposure (SS, N = 9), sham smoke exposure ibuprofen-pretreated (SS-I, N = 10), CSE (N = 9), sham smoke exposure ibuprofen-pretreated (SS-I, N = 10), CSE (N = 9), and CSE ibuprofen-pretreated (CSE-I, N = 19). Ibuprofen (cyclooxygenase eicosanoid inhibitor) was administered as a single daily intramuscular injection (25 mg/kg) for 7 days before the experiment. Cigarette or sham smoke was delivered by syringe in a series of 5, 10, 20, and 30 tidal volume breaths with a 15-min counting period between each subset of breaths to determine 99mTcDTPA biological half-life (T1/2). In the ibuprofen pretreated group, CSE caused significant decreases in 99mTcDTPA T1/2 and dynamic lung compliance. Furthermore, these changes in lung function were accompanied by severe injury to type I alveolar cell epithelium, pulmonary edema, and frequently death of the rabbits. These findings suggest that inhibition of the cyclooxygenase pathway before CSE exacerbates lung injury in rabbits.

• Authors: M L Witten, R J Lemen, S F Quan, R E Sobonya, J L Magarelli, D C Bruck
• Journal: Experimental lung research (Exp Lung Res) Vol. 13 Issue 2 Pg. 113-26 ( 1987) ISSN: 0190-2148 [Print] England
• PMID: 3311720 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Organometallic Compounds
• Smoke
• Thromboxane B2
• 6-Ketoprostaglandin F1 alpha
• Technetium
• Pentetic Acid
• Technetium Tc 99m Pentetate
• Ibuprofen

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Animals
• Female
• Ibuprofen (pharmacology)
• Lung (pathology, ultrastructure)
• Lung Diseases (etiology)
• Male
• Organometallic Compounds (pharmacokinetics)
• Pentetic Acid (pharmacokinetics)
• Plants, Toxic
• Pulmonary Alveoli (metabolism)
• Pulmonary Edema (pathology)
• Rabbits
• Smoke (adverse effects)
• Technetium (pharmacokinetics)
• Technetium Tc 99m Pentetate
• Thromboxane B2 (blood)
• Time Factors
• Tobacco