Inflammasomes in cancer: Effect of epigenetic and autophagic modulations.

Abstract

Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-associated speck-like protein containing caspase activation and recruitment domain (ASC), and the effector, caspase-1, have a significant influence on tumorigenesis but in a tissue-specific and stage-dependent manner. The downstream products of inflammasome activation, that is the proinflammatory cytokines such as IL-1β and IL-18, regulate tissue homeostasis and induce antitumour immune responses, but in contrast, they can also favour cancer growth and proliferation by directing various oncogenic signalling pathways in cancer cells. Moreover, different epigenetic mechanisms, including DNA methylation, histone modification and noncoding RNAs, control inflammasomes and their components by regulating gene expression during cancer progression. Furthermore, autophagy, a master controller of cellular homeostasis, targets inflammasome-induced carcinogenesis by maintaining cellular homeostasis and removing potential cancer risk factors that promote inflammasome activation in support of tumorigenesis. Here, in this review, we summarize the effect of inflammasome activation in cancers and discuss the role of epigenetic and autophagic regulatory mechanisms in controlling inflammasomes. A proper understanding of the interactions among these key processes will be useful for developing novel therapeutic regimens for targeting inflammasomes in cancer.

• Authors: Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Chandra Sekhar Bhol, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Srimanta Patra, Amruta Singh, Shankargouda Patil, Rohan Dhiman, Samir Kumar Patra, Sujit Kumar Bhutia
• Journal: Seminars in cancer biology (Semin Cancer Biol) Vol. 83 Pg. 399-412 (08 2022) ISSN: 1096-3650 [Electronic] England
• PMID: 33039557 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Inflammasomes

Topics

• Autophagy (genetics)
• Carcinogenesis (genetics)
• Epigenesis, Genetic
• Humans
• Inflammasomes (genetics, metabolism)
• Neoplasms (genetics)
• Tumor Microenvironment (genetics)