HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Interleukin-18 (Interleukin 18)

Subscribe to New Research on Interleukin-18

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Also Known As:

Interleukin 18; IL-18; IL18; IFN-gamma Inducing Factor; Interferon-gamma Inducing Factor; IFN gamma Inducing Factor; Inducing Factor, IFN-gamma; Inducing Factor, Interferon-gamma; Interferon gamma Inducing Factor; IFN-gamma-Inducing Factor; Interferon-gamma-Inducing Factor

Networked: 3003 relevant articles (133 outcomes, 544 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dinarello, Charles A: 48 articles (06/2015 - 03/2002)
2.	Okamura, Haruki: 34 articles (01/2016 - 02/2002)
3.	Nakanishi, Kenji: 34 articles (01/2011 - 03/2002)
4.	Kurimoto, M: 30 articles (12/2001 - 01/2000)
5.	Akira, Shizuo: 25 articles (10/2014 - 01/2002)
6.	Okamura, H: 24 articles (03/2004 - 01/2000)
7.	Tsutsui, Hiroko: 23 articles (05/2013 - 03/2002)
8.	Netea, Mihai G: 20 articles (06/2015 - 04/2002)
9.	Dinarello, C A: 19 articles (01/2009 - 01/2000)
10.	Hoshino, Tomoaki: 18 articles (03/2014 - 02/2002)

Related Diseases

1.	Infection 10/01/2007 - "IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. " 10/01/2006 - "In the present study we investigated the immune mechanism of susceptibility to this type of postburn infection and also examined the efficacy of IL-18 treatment. " 08/01/1999 - "In this study, the efficacy of IL-18 on viral infection in mice was investigated. " 07/01/2011 - "We investigated the efficacy of interleukin-18 (IL-18) treatment in postburn MRSA infection. " 04/01/2010 - "We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. "
2.	Neoplasms (Cancer) 06/01/2012 - "Neutralization of IL-18 by RNA interference in tumors or systemically by IL-18-binding protein dramatically reduced the accumulation of Kit(+)CD11b(-) NK cells in tumor bearers. " 10/01/2014 - "Moreover, established distant tumors were completely eradicated by vaccination with the IL-18 and HSV-TK transfectants in combination with GCV. " 10/01/2014 - "Large established tumors of colon 26 transfectants expressing IL-18 and HSV-TK driven by the hTERT promoter were completely eradicated after GCV administration in syngeneic BALB/c mice. " 03/01/2002 - "Construction and analysis of new vector systems with improved interleukin-18 secretion in a xenogeneic human tumor model." 12/01/2006 - "In this article we investigated whether IL-18 genetic modification of tumor cells can increase the efficacy of exosomes derived from IL-18 gene-modified tumor cells. "
3.	Melanoma (Melanoma, Malignant) 04/01/2001 - "Intratumoral IL-18 gene transfer improves therapeutic efficacy of antibody-targeted superantigen in established murine melanoma." 01/01/2010 - "A phase II study of IL-18 in patients with metastatic melanoma confirmed its safety but suggested limited efficacy of IL-18 monotherapy in this setting. " 11/15/2006 - "An exogenous IL-18 treatment improved the ability of the B16F10/IL-18 antisense transfectant cells to migrate, indicating that IL-18 enhanced the migration ability of melanoma cells. " 11/15/2006 - "This study investigated the effect of IL-18 on the ability of murine melanoma cells to migrate by using B16F10 cells and the IL-18 antisense transfectants of B16F10 cells (the B16F10/IL-18 antisense transfectant). " 09/01/2002 - "In this study, we investigated whether the introduction of the interleukin-18 gene to B16F10 melanoma cells can induce antitumor response or not. "
4.	Colitis 07/01/2007 - "In the colitis patients, mean free IL-18 level and IL-18BP were significantly different between healthy individuals and patients, but not between disease remission and exacerbation (167 +/- 32, 492 +/- 247 and 451 +/- 69 pg/ml for IL-18, and 2.1 +/- 1.1, 7.69 +/- 4 and 6.8 +/- 7 ng/ml for IL-18BP, respectively, P= 0.05). " 02/01/2012 - "Remarkably, several reports have demonstrated that immunological or genetic blockage of IL-18 ameliorates the severity of colitis in multiple in vivo models of IBD. " 09/01/2011 - "The aim of this study was to establish a model of murine colitis exacerbated by psychological stress and to clarify the role of IL-18 in this model. " 12/03/2015 - "Colitis and goblet cell loss were rescued in Il18bp(-/-);Il18r(Δ/EC) mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. " 12/03/2015 - "In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. "
5.	Burns 10/15/2002 - "Nevertheless, a single IL-18 injection into mice simultaneously with LPS was no longer effective in the restoration of serum IFN-gamma and IFN-gamma production from the liver MNC at 7 days after burn injury, when mice were considered to be the most immunocompromised. " 01/01/2015 - "The aim of our study was to determine whether combined KIM-1 and IL-18 are more sensitive than traditional markers in detecting kidney injury in patients with burns. " 01/01/2011 - "The purpose of this study was to examine whether EtOH intoxication combined with burn injury influences neutrophil apoptosis and whether IL-18 plays any role in this setting. " 08/01/2015 - "Levels of IL-18 were increased by ∼1.5-fold in the colon as compared to the ileum following alcohol and burn injury. " 01/01/2015 - "Our results suggest that urinary KIM-1 and IL-18 may be used as early, sensitive indicators of AKI in patients with burns of varying degrees and provide clinical clues that can be used in early prevention of AKI."

Related Drugs and Biologics

1.	Interleukin-12 (IL 12)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Cytokines
4.	Messenger RNA (mRNA)
5.	Carbon Monoxide
6.	DNA (Deoxyribonucleic Acid)
7.	Carrier Proteins (Binding Protein)
8.	Interleukins
9.	Interleukin-10 (Interleukin 10)
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Immunotherapy
2.	Injections
3.	Therapeutics
4.	Resuscitation
5.	Aftercare (After-Treatment)