Abstract | INTRODUCTION: METHODS: We conducted an open-label, single-arm intervention trial (study 1, N = 10), and a randomized, double blinded, placebo-controlled trial (study 2, N = 36) to assess the biological activity and safety of niacinamide. Patients with ADPKD were given 30 mg/kg oral niacinamide or placebo, for 12 months. The primary endpoint was the ratio of acetylated p53 to total p53 protein in peripheral blood mononuclear cells (PBMCs). RESULTS: CONCLUSIONS: In conclusion, niacinamide is safe and well-tolerated in patients with ADPKD. However, we were unable to detect a sustained inhibition of sirtuin activity over 12 months of treatment, and there was no signal to suggest a beneficial effect on any efficacy measure.
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Authors | Mireille El Ters, Xia Zhou, Rebecca J Lepping, Pengcheng Lu, Rainer T Karcher, Jonathan D Mahnken, William M Brooks, Franz T Winklhofer, Xiaogang Li, Alan S L Yu |
Journal | Kidney international reports
(Kidney Int Rep)
Vol. 5
Issue 8
Pg. 1271-1279
(Aug 2020)
ISSN: 2468-0249 [Electronic] United States |
PMID | 32775826
(Publication Type: Journal Article)
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Copyright | © 2020 International Society of Nephrology. Published by Elsevier Inc. |