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Niacinamide (Nicotinamide)

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An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

Also Known As:

Nicotinamide; Vitamin B3; 3-Pyridinecarboxamide; Astra Brand of Niacinamide; Enduramide; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Nicobion; Nicotinsäureamid Jenapharm; Papulex; Pharmagenix Brand of Niacinamide; 3 Pyridinecarboxamide; B 3, Vitamin; B3, Vitamin; Jenapharm, Nicotinsäureamid; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Vitamin B 3; Vitamin PP

Networked: 1248 relevant articles (107 outcomes, 191 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Nicotinic Acids: 10
      - Niacinamide: 1248
        Nicorandil: 606
        6-Aminonicotinamide: 95
        cytoflavin: 76
        motesanib diphosphate: 68
        Nikethamide: 52
        N(1)-methylnicotinamide: 23
        N-methylnicotinamide: 23
        nicaraven: 19
        homocysteine-thiolactone-nicotinamide: 13
        nicotinamide-beta-riboside: 13
        isonicotinamide: 11
        CI 1044: 9
        hydrazino nicotinamide: 8
        CD 832: 7
        coamid: 7
        niaprazine: 7
        6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridinecarboxamide: 6
        N-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide: 5
        2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide: 4
        T 86: 4
        ST 71: 3
        5-methylnicotinamide: 2
        6-methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide: 2
        flonicamid: 2
        FR 146801: 2
        glunicate: 2
        N-(2-hydroxyethyl)nicotinamide: 2
        ramixotidine: 2
        S(2) complex: 2
        ST 90: 2
        thiamine drug combination riboflavin niacinamide ascorbic acid amoxicillin: 2
        1,4-dihydro-N-methylnicotinamide: 1
        2-(nicotinoylaminoethanesulfonylamino)pyridine: 1
        2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide: 1
        5-(4-butoxy-3-chlorophenyl)-N-((2-morpholinopyridin-3-yl)methyl)nicotinamide: 1
        diflufenican: 1
        dihydronicotinamide: 1
        FR 76830: 1
        Gelum oral-rd: 1
        hepasteril: 1
        iodo-niacin: 1
        N'-methyl-2-pyridone-5-carboxamide: 1
        N(1)-methyl-4-pyridone-5-carboxamide: 1
        N-(2-(diethylamino)ethyl)-6-fluoronicotinamide: 1
        N-(3-aminobenzyl)-6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide: 1
        N-(hydroxymethyl)nicotinamide: 1
        nicomide: 1
        nicotinamide N-oxide: 1
        nicotinohydroxamic acid: 1
        nifenazone: 1
        succinimidyl 6-hydrazinonicotinate: 1
        thionicotinamide: 1
        tryptamide: 1
        V 3703: 1
        1,1'-trimethylenebisnicotinamide
        1,4-dimethylnicotinamide
        1-(4'-(4''-acetamido-2''-sulphoanilino)-2'-sulphoanilino)-3-(3'-carboxamidopyridino)-2,4,6-sym-triazine-3-amine
        1-benzyl-1,4-dihydronicotinamide dimer
        1-benzylnicotinamide
        1-benzylnicotinamide triflate
        1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide)
        1-methyl-N'-(hydroxymethyl)nicotinamide
        1-methylisonicotinamide
        2-((2,4-dimethoxybenzyl)sulfinyl)-N-(4-pyridyl)nicotinamide
        2-chloronicotinamide
        2-propylisonicotinamide
        3,5-bis((2'-nitroxyethyl)aminocarbonyl)pyridine
        4-methylnicotinamide
        5-ribofuranosyl-3-(aminocarbonyl)-1-methylpyridinium
        5-ribofuranosylnicotinamide
        6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide
        6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide
        6-dimethylaminonicotinamide
        6-hydroxynicotinamide
        6-methyl-N-(3-((3-(1-methylethoxy)propyl)carbamoyl)-1H-pyrazol-4-yl)pyridine-3-carboxamide
        6-methylnicotinamide
        AD 101
        Anticataracticum
        benzyldihydronicotinamide
        dodecylnicotinamide
        hydrazinonictinamide
        L 735286
        LS 82-556
        LY 362884
        menadione nicotinamide bisulfite
        N',N-bis(2-pyridinecarboxamide)-1,2-ethane
        N'-cyano-N-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)isonicotinamidine
        N(1)-ethylnicotinamide
        N(1)-hexylnicotinamide
        N,N'-hexamethylenebis(3-pyridinecarboxamide)
        N-(1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl)isonicotinamide
        N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
        N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide
        N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl)-nicotinamide
        N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxothiazolidin-3-yl)nicotinamide
        N-(2-(4-(2,3-dihydrobenzo(1,4)dioxin-2-ylmethyl)-(1,4)diazepan-2-yl)ethyl)-2-phenoxynicotinamide
        N-(2-(4-methoxyphenyl)-4-oxothiazolidin-3-yl)nicotinamide
        N-(4-pyridyl)isonicotinamide
        N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide
        N-(N-((3-cyanophenyl)sulfonyl)-4-cyclobutylaminoprolyl)-4-((3',5'-dichloroisonicotinoyl)amino)phenylalanine
- Heterocyclic Acids
  - Nicotinic Acids: 10
    - Niacinamide: 1248

Experts

1.	Damian, Diona L: 11 articles (10/2015 - 01/2009)
2.	van der Kogel, Albert J: 10 articles (02/2015 - 03/2002)
3.	Halliday, Gary M: 9 articles (10/2015 - 01/2009)
4.	Hoane, Michael R: 9 articles (06/2015 - 11/2003)
5.	Bussink, Johan: 9 articles (02/2015 - 06/2002)
6.	Kaanders, Johannes H A M: 9 articles (10/2013 - 03/2002)
7.	Li, Da: 8 articles (09/2015 - 12/2009)
8.	Zhou, Shi-Sheng: 8 articles (09/2015 - 12/2009)
9.	Maiese, Kenneth: 7 articles (03/2015 - 05/2003)
10.	Kaanders, Johannes H: 7 articles (02/2015 - 02/2012)

Related Diseases

1.	Neoplasms (Cancer) 04/01/1989 - "Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation." 09/01/2003 - "This discrepancy suggests that the potential chemosensitizing effect of nicotinamide, seen in other studies, is based on a direct effect on tumor cells rather than on an increased delivery of anticancer drugs. " 05/01/2000 - "Future ARCON trials should target selected head and neck tumor localizations and stages, and a lower nicotinamide dose is needed to reduce severe upper gastro-intestinal toxicity." 07/01/1994 - "On the basis of changes in tumor blood flow, oxygenation and metabolite concentrations found in this and other recent studies, possible mechanisms for tumor radiosensitization following nicotinamide administration are considered." 04/01/1992 - "It was concluded that the enhancement of radiation damage in the experimental tumors in mice by nicotinamide, as observed in the present study and reported by others, is due to an increase in intratumor pO2, possibly as a result of an increase in blood perfusion."
2.	Acne Vulgaris 10/01/2012 - "In addition, compared with the simple emollient cream, 0.2% Myrtacine® and 4% vitamin PP decreased acne severity in a significantly greater proportion of patients (P=0.023) and was associated with a better clinical outcome (mild, intermediate, clinically relevant or global improvement; P<0.001). " 12/01/2010 - "The aim of the present study was to formulate a combined patch containing salicylic (SA) acid and nicotinamide (NA), useful for the treatment of mild acne, and to verify their mutual effect on drug permeation and skin retention. " 10/01/2012 - "Patients (age 12-49 years; skin phototype I-IV) with mild-to-moderate acne, who were treated with a topical retinoid for at least one month and had developed skin irritation were assigned to one of the two following treatments: 0.2% Myrtacine® and 4% vitamin PP (N.=116) or a simple emollient cream (N.=48). " 10/01/2012 - "0.2% Myrtacine® and 4% vitamin PP was effective and well tolerated in the treatment of retinoid dermatitis in patients with mild-to-moderate acne and significantly improved acne severity and overall clinical outcome." 11/01/2009 - "Nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, including acne vulgaris. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/01/1998 - "The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical efficacy of high doses of nicotinamide in children at high risk for IDDM. " 03/01/2009 - "It is suggested that nicotinamide might be considered an effective agent for the prevention and treatment of IDDM in prediabetic, and early stages, of IDDM." 01/01/1992 - "To determine the efficacy of nicotinamide in inducing remission in early-onset insulin-dependent diabetes mellitus. " 03/01/2009 - "This study was conducted to investigate the effect of nicotinamide on experimentally-induced IDDM. " 01/01/2001 - "Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT)."
4.	Anoxia (Hypoxia) 10/01/2013 - "This study aimed at detecting nicotinamide's reduction of acute hypoxia in a mouse tumour model by two clinically relevant magnetic resonance imaging (MRI) methods at ultra-high magnetic field strength. " 11/01/1997 - "This study investigates whether nicotinamide with radiation can reduce human tumour hypoxia. " 01/01/2015 - "Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but paradoxically also leads to the development of significant hypoxemia. " 01/01/2012 - "Nicotinamide plays a protective role in hypoxia-induced cardiomyocyte dysfunction. " 01/01/2012 - "Nicotinamide pretreatment protects cardiomyocytes against hypoxia-induced cell death by improving mitochondrial stress."
5.	Ischemia 05/01/2004 - "Nicotinamide improved outcome by 0.287 (95% confidence interval 0.227 to 0.347); it was more effective in temporary ischemia models, after intravenous administration, in animals without comorbidities, and in studies published in full rather than in abstract. " 03/01/2008 - "The aim of the present studies was to determine whether nicotinamide is effective in blunting the negative influence of ischemia/reperfusion to the rat retina in situ and of light to transformed retinal ganglion cells (RGC-5 cells) in culture. " 11/01/2001 - "In this study, we demonstrated that niacinamide, a PARS inhibitor, attenuated ischemia/reperfusion (I/R)-induced liver injury. " 03/01/2008 - "The presented data show that nicotinamide attenuates injury to the retina and RGC-5 cells in culture caused by ischemia/reperfusion and by light, respectively. " 03/01/2008 - "Nicotinamide was administered intraperitoneally just before ischemia and into the vitreous immediately after the insult. "

Related Drugs and Biologics

1.	carbogen
2.	Tetracycline (Achromycin)
3.	Streptozocin (Streptozotocin)
4.	Niacinamide (Nicotinamide)
5.	Glucose (Dextrose)
6.	Niacin (Nicotinic Acid)
7.	NAD (NADH)
8.	Clindamycin (Cleocin)
9.	Insulin (Novolin)
10.	Vitamins

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Renal Dialysis (Hemodialysis)
4.	Chemoprevention
5.	Intraperitoneal Injections