Platelet-derived porous nanomotor for thrombus therapy.

Abstract

The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration of drugs at thrombus site. Here, we develop one kind of mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery of thrombolytic and anticoagulant drugs for thrombus treatment. Regulated by the special proteins on PM, the nanomotors target the thrombus site and then PM can be ruptured under near-infrared (NIR) irradiation to achieve desirable sequential drug release, including rapid release of thrombolytic urokinase (3 hours) and slow release of anticoagulant heparin (>20 days). Meantime, the motion ability of nanomotors under NIR irradiation can effectively promote them to penetrate deeply in thrombus site to enhance retention ratio. The in vitro and in vivo evaluation results confirm that the synergistic effect of targeting ability from PM and motion ability from nanomotors can notably enhance the thrombolysis effect in both static/dynamic thrombus and rat model.

• Authors: Mimi Wan, Qi Wang, Rongliang Wang, Rui Wu, Ting Li, Dan Fang, Yangyang Huang, Yueqi Yu, Leyi Fang, Xingwen Wang, Yinghua Zhang, Zhuoyue Miao, Bo Zhao, Fenghe Wang, Chun Mao, Qing Jiang, Xingquan Xu, Dongquan Shi
• Journal: Science advances (Sci Adv) Vol. 6 Issue 22 Pg. eaaz9014 (05 2020) ISSN: 2375-2548 [Electronic] United States
• PMID: 32766445 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).