Silicon Dioxide (Sand)

Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.

Also Known As:

Networked: 3487 relevant articles (129 outcomes, 456 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lison, Dominique: 20 articles (04/2015 - 09/2002)
2.	Shi, Jianlin: 18 articles (01/2016 - 10/2010)
3.	Holian, Andrij: 17 articles (01/2015 - 02/2004)
4.	Chen, Weihong: 16 articles (11/2015 - 02/2006)
5.	Castranova, V: 16 articles (01/2015 - 01/2000)
6.	Castranova, Vincent: 15 articles (01/2015 - 04/2002)
7.	Ichinose, Takamichi: 14 articles (01/2016 - 11/2005)
8.	Chen, Ying: 14 articles (12/2015 - 01/2009)
9.	Huaux, François: 14 articles (04/2015 - 07/2004)
10.	DeVizio, William: 14 articles (07/2011 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2013 - "The advent of Nanotechnology has paved a way for improved disease treatment strategies, the most noteworthy being the mesoporous silica nanoparticles (MSNs) which have gained much recent attention in the field of cancer therapy and its diagnosis. " 03/22/1999 - "Significant reduction in the cures of EMT6 tumors was also achieved by immunodepletion of helper T cells and inactivation of macrophages by silica treatment. " 06/01/1982 - "In rodents, tumor regression after heating does not occur in immunosuppressed hosts, and the tumor cure rate is significantly reduced by inhibition of macrophage activity with silica; cured immune rats succumb to tumor inoculation when immunosuppressed. " 05/01/2014 - "In this article, we use an alternative cancer model for the evaluation of nanotherapy, and assess the impact of surface functionalization and active targeting of mesoporous silica nanoparticles (MSNPs) on therapeutic efficacy in vivo. " 01/01/2012 - "Here, we report on these recent advances regarding therapeutic efficacy, targeting and safety issues related to the application of mesoporous silica nanoparticles in cancer therapy."
2.	Infection 09/01/1983 - "albicans organisms recovered from the kidneys of silica-treated euthymic mice was similar to the number recovered from saline-treated controls during the first 3 days of infection; however, at every assay period thereafter, the number of organisms recovered from the kidneys of silica-treated mice was dramatically reduced (100- to 1,000-fold). " 01/01/1984 - "Injection of silica caused a marked decrease in the number of esterase-positive macrophages in the peritoneal wash-out population, that may be compatible with the possibility that the cause of the protection is the depletion of target cells for the viral infection. " 07/01/2012 - "Physically altering the components by adding sand significantly improved foraging and infection success for S. " 01/01/2015 - "This study provides insight into changes in the transcriptome of sand pear in response to PBS infection, and the findings have improved our understanding of the resistance mechanism of sand pear to PBS and will facilitate future gene discovery and functional genome studies of sand pear. " 07/01/2015 - "In this study we tested the impact of water salinity, egg density and infection potential of the environment on egg viability in the sand goby (Pomatoschistus minutus), a small fish that exhibits paternal egg care and has a marine origin, but which in the Baltic Sea lives in brackish water. "
3.	Silicosis 03/01/1993 - "The median (range) rate of clearance of 99mTc-DTPA in smokers with silicosis was 4.1 (1.9-12.7) %/minute, which was higher than the rates in non-smoking patients with silicosis of 2.2 (1.1-6.6) %/minute and in smokers without exposure to silica dust of 2.9 (1.6-4.5) %/minute. " 04/29/2005 - "Because no effective treatment for silicosis is available, effective control of exposure to crystalline silica in the workplace is crucial." 12/24/2015 - "In our study, mice were exposed to silica by intratracheal instillation, and in this way we established an experimental silicosis model. " 01/01/2015 - "This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. " 10/01/2014 - "To study potential exposures to crystalline silica and the number of work-related cases of silicosis occurring in Alberta. "
4.	Fibrosis (Cirrhosis) 02/28/2015 - "Here we show that heterozygotic knockout of mdig (mdig+/-) ameliorates silica-induced lung fibrosis by altering the balance between Th17 cells and Treg cells. " 01/01/1985 - "If excitatory substances (such as silica) are eliminated, active fibrosis ends with the restoration of the energy supply. " 08/01/2011 - "This study investigates cross-talk of the related bioactivity mediators in silica-induced pulmonary inflammatory and fibrosis on rats, which contributes to the preventive and therapeutic effect of soluble TNF-α receptor. " 01/01/2010 - "Our study suggests that depletion of Tregs may attenuate the progress of silica-induced lung fibrosis and enhance Th1 response and decelerate Th1/Th2 balance toward a Th2 phenotype in silica-induced lung fibrosis. " 01/01/2010 - "While a dose response study showed similar degrees of fibrosis after silica treatment in the two strains, the RAGE KO mice had some differences in the inflammatory response compared to WT mice. "
5.	Dentin Sensitivity 07/01/2011 - "To evaluate the laboratory dentin occlusion efficacy and effects on dentin permeability of a new multi-benefit dentifrice in order to gain insight into the mechanism of action of a novel technology for dentin hypersensitivity relief based on a specially-designed silica and copolymer system. " 01/01/2009 - "The study also showed that this new arginine toothpaste provided significantly greater reductions (p < 0.05) in dentin hypersensitivity in response to tactile (16.2%, 22.4%, and 21.4%) and air blast (16.2%, 29.2%, and 63.4%) stimuli than the benchmark commercial toothpaste containing 2% potassium ion and 1450 ppm NaF in a silica base, after two, four, and eight weeks of product use, respectively. " 01/01/2010 - "A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity." 01/01/2011 - "The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base. " 01/01/2009 - "The study also showed that the new arginine toothpaste provided significantly greater reductions (p < 0.05) in dentin hypersensitivity in response to tactile (38.9%, 28.8%, and 11.6%) and air blast (16.8%, 26.4%, and 33.8%) stimuli than the benchmark commercial desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride as NaF in a silica base, after two weeks, four weeks, and eight weeks of product use, respectively. "

Related Drugs and Biologics

1.	Dentifrices (Dentifrice)
2.	Sodium Fluoride (Ossin)
3.	Toothpastes
4.	methoxyethylene-maleic anhydride copolymer
5.	Triclosan (pHisoHex)
6.	Fluorides
7.	fluorophosphate (sodium monofluorophosphate)
8.	Arginine (L-Arginine)
9.	Doxorubicin (Adriamycin)
10.	Zinc

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lasers (Laser)
3.	Microspheres (Microsphere)
4.	Tooth Bleaching
5.	Nanospheres