Long non-coding RNAs (
lncRNA) are a type of ncRNA with a length ranging from 200-1,000
nucleotides. Previous studies have confirmed that the
lncRNA Ewing sarcoma associated transcript 1 (EWSAT1) exerts regulatory roles in
cancer development and progression. However, its clinical significance in
glioma remains unknown. In the present study,
RNA-sequencing data from the Gene Expression Omnibus database and The
Cancer Genome Atlas was explored to investigate the association between EWSAT1 expression and prognosis in patients with
glioma. Increased EWSAT1 was associated with the presence of
necrosis on magnetic resonance imaging scans in patients with
glioma. Furthermore, knockdown of EWSAT1 was indicated to suppress the proliferative and invasive abilities of
glioblastoma cell lines using Cell Counting Kit-8 and Transwell assays. Additionally,
microRNA (miR)-152-3p was identified as a potential target of EWSAT1. The present study demonstrated that EWSAT1 interacted directly with miR-152-3p, and rescue experiments confirmed that EWSAT1 participated in
glioma development by suppressing miR-152-3p. These results indicated that EWSAT1 is involved in the occurrence and progression of
glioma, and may serve as a novel target and potential prognostic
biomarker of
glioma treatment.