Abstract |
Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact ( BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.
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Authors | Jiaxiang Bai, Huaiyu Wang, Hao Chen, Gaoran Ge, Miao Wang, Ang Gao, Liping Tong, Yaozeng Xu, Huiling Yang, Guoqing Pan, Paul K Chu, Dechun Geng |
Journal | Biomaterials
(Biomaterials)
Vol. 255
Pg. 120197
(10 2020)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 32563944
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Coated Materials, Biocompatible
- Peptides
- Titanium
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Topics |
- Biomimetics
- Coated Materials, Biocompatible
- Humans
- Inflammation
- Osseointegration
- Osteogenesis
- Peptides
- Surface Properties
- Titanium
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