In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats.

Abstract

Although the anti-diabetic properties of Konjac glucomannan (KGM) have been reported previously; however, the molecular pathways of its anti-diabetic properties are not clear. The present study hypothesized that KGM could mitigate oxidative stress and inflammation. Three doses of KGM (40, 80, 120 mg/kg b.w.) decreased the levels of plasma glucose and insulin in type-2 diabetic rats induced by a high-fat diet and streptozotocin (STZ) after administration for 28 days. Besides, the C-reactive protein, antioxidants, and the pathways of the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) showed amelioration and positively regulation after treated with a medium dose of KGM (80 mg/kg b.w.). The results of the histological study indicated that the medium dose of KGM was able to reverse the structural impairment of kidney and liver caused by type-2 diabetes. In conclusion, our research demonstrated that KGM reduced the hyperglycemia, regulated the Nrf2 pathway and by which it prevented oxidative stress, besides, it reduced the inflammation via regulation of the NF-kB pathway.

• Authors: Yingshu Zhao, Muthukumaran Jayachandran, Baojun Xu
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 159 Pg. 1186-1196 (Sep 15 2020) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 32428590 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Hypoglycemic Agents
• Mannans
• NF-E2-Related Factor 2
• NF-kappa B
• Nfe2l2 protein, rat
• (1-6)-alpha-glucomannan

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage, pharmacology, therapeutic use)
• Antioxidants (administration & dosage, pharmacology, therapeutic use)
• Diabetes Mellitus, Experimental (drug therapy)
• Hypoglycemic Agents (administration & dosage, pharmacology, therapeutic use)
• Kidney (drug effects, metabolism)
• Liver (drug effects, metabolism)
• Male
• Mannans (administration & dosage, pharmacology, therapeutic use)
• NF-E2-Related Factor 2 (metabolism)
• NF-kappa B (metabolism)
• Rats
• Rats, Wistar