Applying Serum Cytokine Levels to Predict Pain Severity in Cancer Patients.

Abstract

BACKGROUND AND AIM:

Cancers originating in the breast, lung and prostate often metastasize to the bone, frequently resulting in cancer-induced bone pain that can be challenging to manage despite conventional analgesic therapy. This exploratory study's aim was to identify potential biomarkers associated with cancer-induced pain by examining a sample population of breast cancer patients undergoing bisphosphonate therapy.

METHODS:

A secondary analysis of the primary study was performed to quantify serum cytokine levels for correlation to pain scores. Cytokines with statistically significant correlations were then input into a stepwise regression analysis to generate a predictive equation for a patient's pain severity. In an effort to find additional potential biomarkers, correlation analysis was performed between these factors and a more comprehensive panel of cytokines and chemokines from breast, lung, and prostate cancer patients.

RESULTS:

Statistical analysis identified nine cytokines (GM-CSF, IFNγ, IL-1β, IL-2, IL-4, IL-5, IL-12p70, IL-17A, and IL-23) that had significant negative correlations with pain scores and they could best predict pain severity through a predictive equation generated for this specific evaluation. After performing a correlation analysis between these factors and a larger panel of cytokines and chemokines, samples from breast, lung and prostate patients showed distinct correlation profiles, highlighting the clinical challenge of applying pain-associated cytokines related to more defined nociceptive states, such as arthritis, to a cancer pain state.

CONCLUSION:

Exploratory analyses such as the ones presented here will be a beneficial tool to expand insights into potential cancer-specific nociceptive mechanisms and to develop novel therapeutics.

• Authors: Jennifer Fazzari, Jesse Sidhu, Shreya Motkur, Mark Inman, Norman Buckley, Mark Clemons, Lisa Vandermeer, Gurmit Singh
• Journal: Journal of pain research (J Pain Res) Vol. 13 Pg. 313-321 ( 2020) ISSN: 1178-7090 [Print] New Zealand
• PMID: 32104053 (Publication Type: Journal Article)
• Copyright: © 2020 Fazzari et al.