Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome.

Abstract

INTRODUCTION:

Polycystic ovary syndrome (PCOS) is characterized by increased central fat mass (CFM), hyper-inflammation, and hemostatic alterations; the risk of cardiovascular disease may also be increased. Reduced fibrin lysability is a risk factor for cardiovascular disease. The present study assessed fibrin lysability in women with PCOS and controls of similar age and body mass index.

MATERIAL AND METHODS:

Ninety women with PCOS and 35 controls of comparable age and body mass index were included. Hemostatic markers (fibrin lysability, fibrinogen, coagulation factor XIII, plasminogen, plasminogen activator inhibitor 1 [PAI-1], plasmin inhibitor, thrombin activatable fibrinolysis inhibitor (TAFI), D-dimer), C-reactive protein (CRP), body mass index, waist-to-hip ratio, CFM determined by Dual-energy X-ray absorptiometry scan, and sex hormones (testosterone estradiol, and sex hormone binding globulin) were determined.

RESULTS:

TAFI and CRP were higher in women with PCOS, than controls. In women with PCOS, fibrin lysability correlated with CFM, waist-to-hip ratio, CRP, fibrinogen, and all hemostatic variables (P ≤ .004) except TAFI and D-dimer. CFM correlated with fibrinogen, CRP, coagulation factor XIII, waist-to-hip ratio, plasminogen, PAI-1, plasmin inhibitor, and TAFI (P < .02). In controls, fibrin lysability correlated with CFM, fibrinogen, coagulation factor XIII, and plasmin inhibitor (P ≤ .02). CFM correlated with PAI-1, plasmin inhibitor, coagulation factor XIII, fibrinogen, and CRP (P ≤ .05). Stepwise regression analysis revealed that fibrin lysability was associated with CFM, fibrinogen and CRP in women with PCOS (r2  = .46, P ≤ .001), but only with CFM in controls (r2  = .28, P < .001).

CONCLUSIONS:

Fibrin lysability was comparable in women with PCOS and controls. Fibrin lysability was associated with CFM and hyper-inflammation in women with PCOS, but only with CFM in controls. These findings suggest that obese women with PCOS and augmented inflammation could have an increased risk of cardiovascular disease.

• Authors: Anne C M Godtfredsen, Johannes J Sidelmann, Jørgen B Gram, Marianne Andersen, Dorte Glintborg
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 99 Issue 8 Pg. 1078-1084 (08 2020) ISSN: 1600-0412 [Electronic] United States
• PMID: 32048272 (Publication Type: Journal Article)
• Copyright: © 2020 Nordic Federation of Societies of Obstetrics and Gynecology.

Chemical References

• Biomarkers
• Gonadal Steroid Hormones
• Fibrin

Topics

• Absorptiometry, Photon
• Adolescent
• Adult
• Biomarkers (blood)
• Cardiovascular Diseases (blood)
• Case-Control Studies
• Female
• Fibrin (metabolism)
• Gonadal Steroid Hormones (blood)
• Humans
• Inflammation (blood)
• Obesity, Abdominal (blood)
• Polycystic Ovary Syndrome (blood)
• Risk Factors