Fibrin

07/01/2015 - "We recently reported the high target uptake and thrombus imaging efficacy of the novel fibrin-specific PET probe (64)Cu-FBP8. "
02/01/1999 - "Safety and thrombus imaging capabilities of the 99mTc-labeled form of a new F(ab')2 monoclonal antibody (MoAb) against fragment D dimers from cross-linked human fibrin, previously shown to be effective labeled to 131I in detecting venous thrombi in the rabbit, were investigated. "
02/01/2014 - "Furthermore, it improved, especially, the knowledge of the early phase of thrombus formation and fibrin generation in vivo. "
08/01/2011 - "In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium."
04/01/2010 - "we tested the efficacy of combining the transcutaneous ultrasound with a pharmacological thrombolysis in the rabbit femoral artery occlusion model with the platelet and fibrin-rich thrombus like AMI. "

02/01/2008 - "This retrospective study found that use of autologous platelet-rich fibrin on a range of hard-to-heal wounds achieved full healing or a significant reduction in wound diameter with no adverse effects. "
08/01/1998 - "No proof exists concerning the osteogenic potential of fibrin sealing (FS); its beneficial effect on bone formation has been questioned even if there is some evidence that FS should influence the early phases of bone repair and may help to solve the problem of reattachment of small osteocartilagenous fragments following joint trauma."
01/01/2015 - "Wounds treated with fibrin demonstrated improved healing in vivo with more perfusion (47%±3% vs. 26%±4%, p<0.01 in placebo) and higher CD34 density score (2.0±0.4 vs. 2.8±0.1, p<0.01) on day 21 with fibrin matrices when compared with placebo-treated wounds. "
05/01/2014 - "In vitro evaluation of antibacterial and antifungal drugs encapsulated fibrin nanoparticles to prove their potential prospect of using these nanocomponent for effective treatment of microbial infested wounds. "
03/01/2013 - "In the new model, a cell-based wound therapy consisting of the application of plasma-derived fibrin dermal scaffolds containing fibroblasts consistently improved the healing response by triggering granulation tissue maturation and further providing a suitable matrix for migrating keratinocytes during wound re-epithelialisation. "

09/01/2013 - "Fibrin Pad is a topical absorbable hemostat designed to be effective in a variety of soft tissues and across multiple bleeding intensities. "
01/01/2013 - "The fibrin pad (FP) is a topical absorbable haemostat designed to be effective in a variety of tissues and across multiple bleeding intensities. "
08/01/1997 - "Our results suggest that fibrin-based dressings will be effective in promotion of hemostasis in arterial bleeding, without compromising blood flow."
08/01/1983 - "However, data are insufficient regarding the relative efficacy of regional vs systemic administration, the proper dose of activator administered regionally, the therapeutic role of the plasma lytic state during regional therapy, the incidence of serious bleeding, and the potential for simpler therapy using new activators with fibrin specificity."
01/01/1973 - "By preventing platelet aggregations and fibrin formation, the permeability alteration could be reduced by 66% and the usual stromal hemorrhages practically eliminated. "

11/01/1985 - "This study provides novel information to indicate that a T-enriched lymphocyte-dependent monocyte-macrophage response to some tumors, before effective in vivo immunization, may participate in initial local protease generation and fibrin deposition, both thought to play a significant role in the local pathobiology of tumors."
08/01/2013 - "The deposition of fibrin along with other pro-coagulant molecules into the extracellular matrix obviously serves as a scaffold to support proliferation, migration and tumor cell growth as well as protection against the immune system. "
10/01/2009 - "Fibrin clot inhibitor medication and efficacy of bacillus Calmette-Guerin for bladder urothelial cancer."
01/01/2016 - "In this study, a unique "microenvironment" was confirmed upon introduction of cancer cells of different types into circulation where activated platelets and fibrin were physically associated with blood-borne cancer cells. "
05/01/2006 - "These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. "

09/01/2012 - "Microscopically, there was decreased inflammation, improved granulation, and earlier onset of fibrin filament deposition, possibly leading to enhanced wound healing. "
05/01/2006 - "Incorporating IGF into a fibrin clot placed in an equine cartilage defect improved the quality and quantity of repair tissue and reduced synovial inflammation. "
01/01/2013 - "To date, preclinical animal studies have demonstrated feasibility of both standalone NIRF intravascular imaging as well as dual-modality approaches detecting inflammation and fibrin deposition in coronary-sized arteries. "
01/12/2012 - "Altogether, the present study identified VLDLR as a novel endothelial cell receptor for fibrin that promotes fibrin-dependent leukocyte transmigration and thereby inflammation. "
06/01/2011 - "Histopathological studies demonstrated less significant granulomatous inflammation in the fibrin groups as well as better overall axonal regeneration, fiber alignment, and recovery of nerve conduction velocities. "