Abstract | SCOPE: METHODS AND RESULTS: Preliminary antioxidant and neuroinflammatory experiments are carried out with 15 drink polyphenolic extracts in SH-SY5Y and BV2 cells, using H2 O2 as pro-oxidant and LPS as pro-inflammatory stimulus, respectively. Extracts improve antioxidant systems functioning and present neuroprotective mitochondrial-related effects. In microglia, extracts reduce reactive oxygen species and modulate cytokine release. To better mimic human consumption, four concentrated dealcoholized apple-derived drinks (three ciders and apple juice) are supplied to mice for 7 days in substitution of drinking water. Mice treated with beverages present reduced brain oxidative stress and inflammatory markers after LPS injection. Interestingly, genetic expression of antioxidant enzymes and glutathione levels are also greatly augmented after drink intake. CONCLUSION: The results confirm the antioxidant and anti-inflammatory-mediated neuroprotective properties of apple-derived drinks, suggesting that their consumption could be a good approach for prevention of neurodegenerative disorders. To the authors' knowledge, this is the first description of cider neuroprotective effects.
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Authors | Rebeca Alvariño, Eva Alonso, Amparo Alfonso, Luis M Botana |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 64
Issue 2
Pg. e1901017
(01 2020)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 31837654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antioxidants
- Cytokines
- Lipopolysaccharides
- Neuroprotective Agents
- Plant Extracts
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Topics |
- Animals
- Antioxidants
(chemistry, physiology)
- Brain
(drug effects, metabolism)
- Cell Line
- Cytokines
(metabolism)
- Disease Models, Animal
- Female
- Fruit and Vegetable Juices
- Inflammation
(chemically induced, diet therapy, prevention & control)
- Lipopolysaccharides
(toxicity)
- Malus
(chemistry)
- Mice
- Microglia
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Oxidative Stress
(drug effects)
- Plant Extracts
(chemistry, pharmacology)
- Spain
- Wine
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