Abstract | BACKGROUND: METHODS: Totally 225 acute pancreatitis (AP) patients (including 75 SAP, 75 moderate-severe acute pancreatitis [MSAP], and 75 mild acute pancreatitis [MAP] patients) were recruited based on the Atlanta classification, and their serum samples were obtained within 24 hours after admission. Meanwhile, 75 health controls (HCs) were recruited with their serum samples collected at the enrollment. The serum suPAR was then detected using enzyme-linked immunosorbent assay. RESULTS: The suPAR level was increased in SAP patients compared with MSAP patients (P = .023), MAP patients (P < .001), and HCs (P < .001). Receiver operating characteristic (ROC) curve presented that suPAR could not only differentiate SAP patients from HCs (AUC: 0.920, 95%CI: 0.875-0.965) but also differentiate SAP patients from MSAP (AUC: 0.684, 95%CI: 0.600-0.769) and MAP patients (AUC: 0.855, 95%CI: 0.797-0.912). In SAP patients, suPAR was positively correlated with Ranson score (P < .001), acute physiology and chronic healthcare evaluation II score (P = .001), sequential organ failure assessment score (P < .001), and C-reaction protein (P = .002). Further ROC curve exhibited that suPAR (AUC: 0.806, 95%CI: 0.663-0.949) was of good value in predicting increased inhospital mortality of SAP patients. CONCLUSION:
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Authors | Qi Zhang, Le Li, Hongze Chen, Guangquan Zhang, Siqiang Zhu, Rui Kong, Hua Chen, Gang Wang, Bei Sun |
Journal | Journal of clinical laboratory analysis
(J Clin Lab Anal)
Vol. 34
Issue 3
Pg. e23097
(Mar 2020)
ISSN: 1098-2825 [Electronic] United States |
PMID | 31774228
(Publication Type: Journal Article)
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Copyright | © 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. |
Chemical References |
- Biomarkers
- Receptors, Urokinase Plasminogen Activator
|
Topics |
- Biomarkers
(blood)
- Case-Control Studies
- Female
- Hospital Mortality
- Humans
- Inflammation
(blood)
- Male
- Middle Aged
- Pancreatitis
(blood, mortality)
- Prognosis
- ROC Curve
- Receptors, Urokinase Plasminogen Activator
(blood)
- Risk Factors
- Severity of Illness Index
- Solubility
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