Inflammation, oxidative stress and altered heat shock response in type 2 diabetes: the basis for new pharmacological and non-pharmacological interventions.

Abstract

Type 2 diabetes mellitus (DM2) is a chronic disease characterised by variable degrees of insulin resistance and impaired insulin secretion. Besides, several pieces of evidence have shown that chronic inflammation, oxidative stress, and 70 kDa heat shock proteins (HSP70) are strongly involved in DM2 and its complications, and various pharmacological and non-pharmacological treatment alternatives act in these processes/molecules to modulate them and ameliorate the disease. Besides, uncontrolled hyperglycaemia is related to several complications as diabetic retinopathy, neuropathy and hepatic, renal and cardiac complications. In this review, we address discuss the involvement of different inflammatory and pro-oxidant pathways related to DM2, and we described molecular targets modulated by therapeutics currently available to treat DM2.

• Authors: Gabriela Elisa Hirsch, Thiago Gomes Heck
• Journal: Archives of physiology and biochemistry (Arch Physiol Biochem) Vol. 128 Issue 2 Pg. 411-425 (Apr 2022) ISSN: 1744-4160 [Electronic] England
• PMID: 31746233 (Publication Type: Journal Article, Review)

Topics

• Diabetes Mellitus, Type 2 (complications, metabolism, therapy)
• Heat-Shock Response
• Humans
• Inflammation (metabolism)
• Insulin Resistance
• Oxidative Stress