Evaluation of Parameters for Cancer-Induced Sarcopenia in Patients Autopsied after Death from Colorectal Cancer.

Abstract

Cachexia frequently occurs in cancer patients and is correlated with reduced therapeutic responsiveness and poor prognosis. Although skeletal muscle atrophy is an important factor related to cachexia, biomarkers for its early diagnosis are not yet definitive. In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia. SDS-MYL1 was positively correlated to SMI and TNF-α was negatively correlated, but the other factors did not show any correlations with SMI. Multivariate analysis showed that of the 3 cytokines, TNF-α and HMGB1 were correlated with SMI. Furthermore, when the biochemical skeletal muscle maturation marker, SDS-MYL1, was compared with serum cytokines, TNF-α and HMGB1 were negatively correlated but IL-6 was not. In multivariate analysis, only TNF-α was associated with SDS-MYL1. A positive correlation was found between TNF-α and HMGB1. These findings suggest that since TNF-α was inversely correlated with SMI and SDS-MYL1, TNF-α is a serum marker of skeletal muscle atrophy in CRC. Moreover, SDS-MYL1 might be established as a biomarker linked to clinical sarcopenia in experiments in vitro and in vivo.

• Authors: Hitoshi Ohmori, Isao Kawahara, Takuya Mori, Shota Nukaga, Yi Luo, Shingo Kishi, Rina Fujiwara-Tani, Shiori Mori, Kei Goto, Takamitsu Sasaki, Hiroki Kuniyasu
• Journal: Pathobiology : journal of immunopathology, molecular and cellular biology (Pathobiology) Vol. 86 Issue 5-6 Pg. 306-314 ( 2019) ISSN: 1423-0291 [Electronic] Switzerland
• PMID: 31707381 (Publication Type: Evaluation Study, Journal Article)
• Copyright: © 2019 S. Karger AG, Basel.

Chemical References

• Biomarkers
• HMGB1 Protein
• HMGB1 protein, human
• IL6 protein, human
• Interleukin-6
• Myosin Light Chains
• Tumor Necrosis Factor-alpha
• myosin light chain I

Topics

• Aged
• Aged, 80 and over
• Autopsy
• Biomarkers (blood)
• Cachexia (diagnosis)
• Colorectal Neoplasms (complications, pathology)
• Female
• HMGB1 Protein (blood)
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged
• Muscle, Skeletal (metabolism)
• Myosin Light Chains (metabolism)
• Sarcopenia (etiology, pathology)
• Tumor Necrosis Factor-alpha (blood)