Estradiol/testosterone and estradiol/androstenedione indexes and nutritional status in PCOS women - A pilot study.

Abstract

OBJECTIVE:

The aim of the study was to analyze interrelations between estradiol/testosterone (E2/T) and estradiol/androstenedione (E2/A) indexes and nutritional status, insulin resistance in PCOS.

STUDY DESIGN:

A cross-sectional study involved 76 PCOS (41 obese) and 67 Non-PCOS (40 obese) women. Anthropometric parameters and body composition were assessed. In fasting state of serum glucose, androgens, estradiol, FSH, LH, SHBG and insulin were measured. E2/T and E2/A indexes and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated.

RESULTS:

The values of E2/T and E2/A indexes were significantly lower in the PCOS than Non-PCOS subjects, but did not differ significantly between the obese and normal weight groups. The lowest E2/T and E2/A values were observed in the normal weight PCOS group. Multivariable regression analyses revealed that the presence of PCOS was the major factor affecting both the log10 E2/T (β = -0.16) and log10 E2/A (β = -0.15) indexes. In addition, log10 E2/A index variability was explained by percentage of body fat (β = 0.57). HOMA-IR was not among the explanatory factors in all above models.

COMMENT:

The E2/A index is more affected by nutritional status than E2/T index. The lower value of both indices in PCOS women with normal body mass suggest that aromatase activity in PCOS are related to nutritional status.

• Authors: Grzegorz Franik, Marta Maksym, Aleksander J Owczarek, Jerzy Chudek, Paweł Madej, Magdalena Olszanecka-Glinianowicz
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 242 Pg. 166-169 (Nov 2019) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 31600717 (Publication Type: Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Chemical References

• Testosterone
• Androstenedione
• Estradiol

Topics

• Androstenedione (blood)
• Case-Control Studies
• Cross-Sectional Studies
• Estradiol (blood)
• Female
• Humans
• Obesity (blood, complications)
• Pilot Projects
• Polycystic Ovary Syndrome (blood, complications)
• Testosterone (blood)