Abstract |
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Current studies have shown that the Th17/Treg immune balance may be involved in the occurrence of IgAN, but the exact mechanism is still unclear. Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catalyses degradation of tryptophan (Trp) through the kynurenine (Kyn) pathway; it can control inflammation and immune response by inducing Trp starvation. IDO may be a key molecule in regulating the Th17/Treg immune balance. However, it is not clear whether IDO is involved in the IgAN disease occurrence by regulating the Th17/Treg immune balance. In this study, an IgAN mouse model was established. The mice were intraperitoneally inoculated with IDO inhibitor 1-MT or agonist ISS-ODN to observe whether the IDO signalling pathway participates in the occurrence and development of IgAN by regulating the Th17/Treg immune balance. The results showed that IDO inhibitor 1-MT significantly increased renal injury and glomerular IgA accumulation and up-regulated Th17/Treg and Th17-related cytokine expression in IgAN mice, while ISS-ODN significantly decreased renal injury and glomerular IgA accumulation, down-regulated Th17/Treg expression and inhibited Th17-related cytokine expression in IgAN mice. In conclusion, IDO was involved in the occurrence and progress of IgAN by regulating the Th17/ Treg balance.
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Authors | Y Yang, K Liu, Y Chen, Y Gong, Y Liang |
Journal | Folia biologica
(Folia Biol (Praha))
Vol. 65
Issue 2
Pg. 101-108
( 2019)
ISSN: 0015-5500 [Print] Czech Republic |
PMID | 31464185
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Indoleamine-Pyrrole 2,3,-Dioxygenase
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Topics |
- Animals
- Cytokines
(metabolism)
- Female
- Glomerulonephritis, IGA
(enzymology, immunology)
- Immunity
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(metabolism)
- Kidney
(injuries, metabolism, pathology)
- Mice, Inbred BALB C
- Signal Transduction
- T-Lymphocytes, Regulatory
(immunology)
- Th17 Cells
(immunology)
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