[Hypercorticism during streptozotocin diabetes and mifepristone administration: the role of cyclic adenosine monophosphate].

Abstract

It was studed basal and ACTH-stimulated production of cyclic adenosine monophosphate (cAMP) and corticosteroid hormones (progesterone and corticosterone) in rat adrenals in vitro under streptozotocin diabetes, in conditions of mifepristone administration and their combination. It was shown that in streptozotocin diabetes animals, both the basal and adrenocorticotropic hormone (ACTH) stimulated cAMP production significantly increased; this was accompanied by the increase in basal and ACTH-stimulated progesterone and corticosterone production in rat adrenals in vitro. Repeated administration of mifepristone to control and diabetic rats caused an increase mainly in ACTH-stimulated production of the main glucocorticoid hormone, corticosterone, without additional changes in the cAMP level. The results obtained suggest activation of two mechanisms of steroidogenesis enhancement in experimental animals. In rats with streptozotocin diabetes, both basal and ACTH-stimulated activity of all stages of steroidogenesis increase, which is mediated by the increased formation of cAMP as second messenger mediating the ACTH action on adrenocortical cells. Prolonged administration of mifepristone to control and diabetic rats resulted in increased activity of only late stages of steroidogenesis with predominant elevation of synthesis of physiologically active hormone corticosterone without additional changes in cAMP production level.

• Authors: V G Selyatitskaya, E D Afonnikova, N A Pal Chikova, O I Kuz Minova
• Journal: Biomeditsinskaia khimiia (Biomed Khim) Vol. 65 Issue 4 Pg. 311-315 (Jun 2019) ISSN: 2310-6972 [Print] Russia (Federation)
• Vernacular Title: Giperkortitsizm pri streptozototsinovom diabete i vvedenii mifepristona: rol' tsiklicheskogo adenozinmonofosfata.
• PMID: 31436172 (Publication Type: Journal Article)

Chemical References

• Mifepristone
• Adrenocorticotropic Hormone
• Cyclic AMP
• Corticosterone

Topics

• Adrenocortical Hyperfunction (complications, physiopathology)
• Adrenocorticotropic Hormone (physiology)
• Animals
• Corticosterone (physiology)
• Cyclic AMP (physiology)
• Diabetes Mellitus, Experimental (complications, drug therapy)
• Mifepristone (pharmacology)
• Rats