The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.

Abstract

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

• Authors: Eleanor L Watts, Aurora Perez-Cornago, Paul N Appleby, Demetrius Albanes, Eva Ardanaz, Amanda Black, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, S A Paul Chubb, Michael B Cook, Mélanie Deschasaux, Jenny L Donovan, Dallas R English, Leon Flicker, Neal D Freedman, Pilar Galan, Graham G Giles, Edward L Giovannucci, Marc J Gunter, Laurel A Habel, Christel Häggström, Christopher Haiman, Freddie C Hamdy, Serge Hercberg, Jeff M Holly, Jiaqi Huang, Wen-Yi Huang, Mattias Johansson, Rudolf Kaaks, Tatsuhiko Kubo, J Athene Lane, Tracy M Layne, Loic Le Marchand, Richard M Martin, E Jeffrey Metter, Kazuya Mikami, Roger L Milne, Howard A Morris, Lorelei A Mucci, David E Neal, Marian L Neuhouser, Steven E Oliver, Kim Overvad, Kotaro Ozasa, Valeria Pala, Claire H Pernar, Michael Pollak, Mari-Anne Rowlands, Catherine A Schaefer, Jeannette M Schenk, Pär Stattin, Akiko Tamakoshi, Elin Thysell, Mathilde Touvier, Antonia Trichopoulou, Konstantinos K Tsilidis, Stephen K Van Den Eeden, Stephanie J Weinstein, Lynne Wilkens, Bu B Yeap, Timothy J Key, Naomi E Allen, Ruth C Travis
• Journal: International journal of cancer (Int J Cancer) Vol. 145 Issue 12 Pg. 3244-3256 (12 15 2019) ISSN: 1097-0215 [Electronic] United States
• PMID: 30873591 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

Chemical References

• Biomarkers, Tumor
• Insulin-Like Growth Factor Binding Proteins
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II

Topics

• Adult
• Aged
• Aged, 80 and over
• Anthropometry (methods)
• Biomarkers, Tumor (blood, metabolism)
• Cross-Sectional Studies
• Humans
• Insulin-Like Growth Factor Binding Proteins (blood)
• Insulin-Like Growth Factor I (metabolism)
• Insulin-Like Growth Factor II (metabolism)
• Male
• Middle Aged
• Neoplasms (blood, etiology, metabolism)
• Prospective Studies
• Young Adult