Abstract | BACKGROUND/AIM: PATIENTS AND METHODS: Metabolomic analysis of serum samples from 26 patients with ESCC that were collected before neoadjuvant chemoradiotherapy was performed. The metabolites associated with hematological toxicity or nephrotoxicity were evaluated. RESULTS: CONCLUSION: Our study found that serum levels of some metabolites differed significantly between patients with and without hematological or renal side-effects. These metabolites may be useful biomarkers for predicting hematological toxicity or nephrotoxicity after neoadjuvant chemoradiotherapy for ESCC.
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Authors | Shin Nishiumi, Seiji Fujigaki, Takashi Kobayashi, Takashi Kojima, Yoshinori Ito, Hiroyuki Daiko, Ken Kato, Hirokazu Shoji, Yuzo Kodama, Kazufumi Honda, Masaru Yoshida |
Journal | Anticancer research
(Anticancer Res)
Vol. 39
Issue 1
Pg. 519-526
(Jan 2019)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 30591504
(Publication Type: Journal Article)
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Copyright | Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Biomarkers, Pharmacological
- Biomarkers, Tumor
- Cisplatin
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Topics |
- Adult
- Aged
- Biomarkers, Pharmacological
(blood)
- Biomarkers, Tumor
(blood)
- Chemoradiotherapy
(adverse effects)
- Cisplatin
(adverse effects)
- Combined Modality Therapy
(adverse effects)
- Esophageal Squamous Cell Carcinoma
(blood, drug therapy, pathology, radiotherapy)
- Female
- Humans
- Male
- Metabolomics
- Middle Aged
- Neoadjuvant Therapy
(adverse effects)
- Quality of Life
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