Phosphatidylethanolamines (Cephalins)

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.

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Networked: 167 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Michailidis, George: 4 articles (12/2020 - 12/2018)
2.	Pennathur, Subramaniam: 4 articles (12/2020 - 12/2018)
3.	Domingues, Pedro: 4 articles (12/2013 - 04/2012)
4.	Afshinnia, Farsad: 3 articles (12/2020 - 01/2019)
5.	Rajendiran, Thekkelnaycke M: 3 articles (12/2020 - 12/2018)
6.	Soni, Tanu: 3 articles (12/2020 - 12/2018)
7.	Moon, Myeong Hee: 3 articles (01/2014 - 03/2009)
8.	Domingues, M Rosário M: 3 articles (12/2013 - 10/2013)
9.	Byun, Jaeman: 2 articles (12/2020 - 11/2019)
10.	Sharma, Kumar: 2 articles (11/2019 - 01/2019)

Related Diseases

1.	Asthma (Bronchial Asthma) 06/01/2021 - "In particular, levels of fatty acids, acylcarnitines, phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, triglycerides, and diacylglycerols were altered during asthma remission. "
2.	Liver Diseases (Liver Disease) 04/01/1955 - "[The cephalin test and its differential diagnostic significance in liver diseases]." 08/01/1951 - "[Thymol and cephalin test in liver diseases]." 06/01/1950 - "Studies with the quantitative cephalin-cholesterol flocculation reaction; effect of temperature variation; serum protein patterns in liver disease." 07/01/1949 - "Studies with the quantitative cephalin cholesterol flocculation reaction; effect of variation in temperature at which Hanger reaction occurs; the protein patterns of normal and abnormal liver-disease sera." 08/01/1949 - "Cholesterol-desoxycholic acid; a stable antigen for use in a flocculation test for liver dysfunction; comparison with the Hanger cephalin-cholesterol test."
3.	Neoplasms (Cancer) 07/01/1974 - "The acyl groups of ethanolamine phosphoglycerides in tumor microsomes had relatively more 18:1, 18:2, and 20:4(n - 6) and less 18:0, 22:4(n - 6), and 22:6(n - 3) than the adult brain gray matter. " 07/01/1974 - "Except for the increase in 18:2, acyl group changes in choline phosphoglycerides between tumors and controls were not as extensive as in the ethanolamine phosphoglycerides. " 07/01/1991 - "These 1-alkenyl ethanolamine phosphoglycerides are major phospholipids in brain, vascular tissue, neutrophils, and most tumors, and they constitute 15-20% of total phospholipids in cultured glioma cell. " 02/05/2023 - "Also, the levels of lipids such as phosphatidylcholines and phosphatidylethanolamines were again lower and their relative abundances in the organic phase of GB cancer samples were different from those of other samples. " 12/01/2018 - "Within UCB, there was a progressive decrease in the levels of phosphatidylserine (PS), phosphatidylethanolamines (PEs), and phosphocholines, whereas an increase in the levels of diacylglycerols (DGs) with tumor stage. "
4.	Thrombosis (Thrombus) 07/20/1935 - "The addition of an excess of platelets, whether normal, hemophilic, or animal in origin, accelerates thrombin production and makes hemophilic blood clot normally; but cephalin, despite the fact that it accelerates thrombin production in normal plasma, is unexplainedly ineffective when added to hemophilic plasma." 04/01/1993 - "Thrombosis was induced by slow injection of kaolin-cephalin suspension after frontal and caudal ligation of the sagittal sinus in rats. " 05/01/1968 - "Studies of thrombus formation and fatty acid composition of serum lecithins and cephalins in man during high sugar and starch diets." 07/03/2017 - "Concurrent experiments showed that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generation and active provision of a procoagulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosphatidylethanolamines. " 06/01/2001 - "In an effort to reduce the risks of a possible iatrogenic transmission of bovine spongiform encephalitis (BSE) through the use of bovine-derived medicinal products, we patented in the USA in 1999 a polysaccharide from brown algae, endowed with interesting pharmacological activities: (a) concentration-dependent inhibition of thromboplastin or cephalin-kaolin-induced thrombin generation from platelets, (b) concentration-dependent inhibition of thrombin-induced platelet aggregation, (c) thrombin has hypotensive effect, which was blunted and zeroed by our fucansulfate in a dose-dependent way, (d) when aortae are stimulated with thrombin, they become stickier for polymorphonucleated leukocytes (PMNs); our fucansulfate decreased concentration-dependently, PMNs sticking to autologous rabbit aortae, (e) dose-dependent inhibition of thrombin-induced thrombosis. "
5.	Hepatitis 06/01/1946 - "Cephalin flocculation test in the detection of pre-icteric infective hepatitis and the prevention of homologous serum jaundice." 05/01/1945 - "MECHANISM OF THE POSITIVE CEPHALIN-CHOLESTEROL FLOCCULATION REACTION IN HEPATITIS." 05/01/1950 - "Comparison of the thymol, cephalin-cholesterol flocculation and colloidal red tests in acute viral hepatitis." 07/14/1950 - "[Hepatitis during the course of bartonellosis (Carrion's disease) study of 2 cases with hepatobiliary function tests with special reference to the colloidal gold and cephalin-cholesterol reactions]."

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)
2.	Phosphatidylcholines (Phosphatidylcholine)
3.	Triglycerides (Triacylglycerol)
4.	Phosphatidylinositols (Phosphatidylinositol)
5.	Diglycerides
6.	Cholesterol
7.	Kaolin
8.	Fibrinogen (Factor I)
9.	N-(4-aminophenethyl)spiroperidol (NAPS)
10.	Lecithins

Related Therapies and Procedures

1.	Ligation